KIF22 (kinesin family member 22)

2013-06-01  

Identity

HGNC
KIF22
LOCATION
16p11.2
LOCUSID
3835
ALIAS
A-328A3.2,KID,KNSL4,OBP,OBP-1,OBP-2,SEMDJL2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3835
MIM: 603213
HGNC: 6391
Ensembl: ENSG00000079616

Variants:

dbSNP: 3835
ClinVar: 3835
TCGA: ENSG00000079616
COSMIC: KIF22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079616ENST00000160827Q14807
ENSG00000079616ENST00000400751Q14807
ENSG00000079616ENST00000400751A0A024R632
ENSG00000079616ENST00000561482Q14807
ENSG00000079616ENST00000561482A0A024R632
ENSG00000079616ENST00000568312I3L306
ENSG00000079616ENST00000569382H3BRB3
ENSG00000079616ENST00000569636H3BTH5
ENSG00000079616ENST00000570173H3BQB9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387132522024KIF22 promotes multiple myeloma progression by regulating the CDC25C/CDK1/cyclinB1 pathway.0
387132522024KIF22 promotes multiple myeloma progression by regulating the CDC25C/CDK1/cyclinB1 pathway.0
379441972023KIF22 promotes the proliferation and glycolysis of melanoma by activating EGFR/STAT3 signaling.0
379441972023KIF22 promotes the proliferation and glycolysis of melanoma by activating EGFR/STAT3 signaling.0
355787242022KIF22 Promotes Development of Pancreatic Cancer by Regulating the MEK/ERK/P21 Signaling Axis.4
355787242022KIF22 Promotes Development of Pancreatic Cancer by Regulating the MEK/ERK/P21 Signaling Axis.4
316576172020Suppression of KIF22 Inhibits Cell Proliferation and Xenograft Tumor Growth in Colon Cancer.6
320901032020Suppression of KIF22 Inhibits Cell Proliferation and Xenograft Tumor Growth in Tongue Squamous Cell Carcinoma.3
316576172020Suppression of KIF22 Inhibits Cell Proliferation and Xenograft Tumor Growth in Colon Cancer.6
320901032020Suppression of KIF22 Inhibits Cell Proliferation and Xenograft Tumor Growth in Tongue Squamous Cell Carcinoma.3
303588522019Detecting genetic modifiers of spondyloepimetaphyseal dysplasia with joint laxity in the Caucasian Afrikaner community.2
303588522019Detecting genetic modifiers of spondyloepimetaphyseal dysplasia with joint laxity in the Caucasian Afrikaner community.2
293827842018KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation.21
293827842018KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation.21
257432052015Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules.20

Citation

Dessen P

KIF22 (kinesin family member 22)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53339/kif22-(kinesin-family-member-22)