Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 22937
MIM: 601510
HGNC: 30634
Ensembl: ENSG00000114650
Variants:
dbSNP: 22937
ClinVar: 22937
TCGA: ENSG00000114650
COSMIC: SCAP
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Metabolism of lipids and lipoproteins | REACTOME | R-HSA-556833 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | REACTOME | R-HSA-1655829 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444516 | Hypercholesterolemia | Disease | ClinicalAnnotation | associated | PD | 16158080 | |
| PA448500 | atorvastatin | Chemical | ClinicalAnnotation | associated | PD | 18435918 | |
| PA451363 | simvastatin | Chemical | ClinicalAnnotation | associated | PD | 16158080 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37979395 | 2024 | SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway. | 1 |
| 38256181 | 2024 | The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis. | 5 |
| 37979395 | 2024 | SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway. | 1 |
| 38256181 | 2024 | The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis. | 5 |
| 37437369 | 2023 | Deficiency of SCAP inhibits HBV pathogenesis via activation of the interferon signaling pathway. | 1 |
| 37437369 | 2023 | Deficiency of SCAP inhibits HBV pathogenesis via activation of the interferon signaling pathway. | 1 |
| 32432943 | 2021 | Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway. | 21 |
| 33156328 | 2021 | The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites. | 16 |
| 33446483 | 2021 | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. | 30 |
| 34192549 | 2021 | Structural basis for sterol sensing by Scap and Insig. | 11 |
| 34487377 | 2021 | PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability. | 14 |
| 32432943 | 2021 | Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway. | 21 |
| 33156328 | 2021 | The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites. | 16 |
| 33446483 | 2021 | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. | 30 |
| 34192549 | 2021 | Structural basis for sterol sensing by Scap and Insig. | 11 |
Citation
Dessen P
SCAP (SREBF chaperone)
Atlas Genet Cytogenet Oncol Haematol. 2013-06-01
Online version: http://atlasgeneticsoncology.org/gene/53340/scap-(srebf-chaperone)
