LYPLA1 (lysophospholipase 1)

2013-06-01  

Identity

HGNC
LYPLA1
LOCATION
8q11.23
LOCUSID
10434
ALIAS
APT-1,APT1,LPL-I,LPL1,hAPT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10434
MIM: 605599
HGNC: 6737
Ensembl: ENSG00000120992

Variants:

dbSNP: 10434
ClinVar: 10434
TCGA: ENSG00000120992
COSMIC: LYPLA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120992ENST00000316963O75608
ENSG00000120992ENST00000316963Q6IAQ1
ENSG00000120992ENST00000343231O75608
ENSG00000120992ENST00000518546E5RGR0
ENSG00000120992ENST00000521352E5RJ48
ENSG00000120992ENST00000521898E5RI35
ENSG00000120992ENST00000522007E5RFT6
ENSG00000120992ENST00000618741A0A087X1K9
ENSG00000120992ENST00000618914B4DP64

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Glycerophospholipid metabolismKEGGhsa00564
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
MetabolismREACTOMER-HSA-1430728
Metabolism of nitric oxideREACTOMER-HSA-202131
eNOS activation and regulationREACTOMER-HSA-203765
eNOS activationREACTOMER-HSA-203615

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381798772024A conserved but structurally divergent loop in acyl protein thioesterase 1 regulates its catalytic activity, ligand binding, and folded stability.0
383448002024Depalmitoylation and cell physiology: APT1 as a mediator of metabolic signals.0
381798772024A conserved but structurally divergent loop in acyl protein thioesterase 1 regulates its catalytic activity, ligand binding, and folded stability.0
383448002024Depalmitoylation and cell physiology: APT1 as a mediator of metabolic signals.0
349845782022LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in Cervical Cancer by the miR-526b-5p /LYPLA1 Axis.5
349845782022LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in Cervical Cancer by the miR-526b-5p /LYPLA1 Axis.5
304311032019Inhibition of cell proliferation and migration in non‑small cell lung cancer cells through the suppression of LYPLA1.13
304828052019Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.22
304311032019Inhibition of cell proliferation and migration in non‑small cell lung cancer cells through the suppression of LYPLA1.13
304828052019Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.22
292959572018The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division.10
293623702018Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes.40
292959572018The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division.10
293623702018Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes.40
256706282015miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.23

Citation

Dessen P

LYPLA1 (lysophospholipase 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53380/lypla1-(lysophospholipase-1)