SLC6A19 (solute carrier family 6 member 19)

2013-06-01  

Identity

HGNC
LOCATION
5p15.33
LOCUSID
ALIAS
B0AT1,HND
FUSION GENES

Other Information

Locus ID:

NCBI: 340024
MIM: 608893
HGNC: 27960
Ensembl: ENSG00000174358

Variants:

dbSNP: 340024
ClinVar: 340024
TCGA: ENSG00000174358
COSMIC: SLC6A19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174358ENST00000304460Q695T7
ENSG00000174358ENST00000515652E9PD72

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Na+/Cl- dependent neurotransmitter transportersREACTOMER-HSA-442660

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
321321842020Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.2943
330641472020Unraveling the Role of ACE2, the Binding Receptor for SARS-CoV-2, in Inflammatory Bowel Disease.11
321321842020Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.2943
330641472020Unraveling the Role of ACE2, the Binding Receptor for SARS-CoV-2, in Inflammatory Bowel Disease.11
311766872019A missense mutation in SLC6A1 associated with Lennox-Gastaut syndrome impairs GABA transporter 1 protein trafficking and function.30
311766872019A missense mutation in SLC6A1 associated with Lennox-Gastaut syndrome impairs GABA transporter 1 protein trafficking and function.30
255344292015Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors.196
255344292015Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors.196
232348562012Up-regulation of amino acid transporter SLC6A19 activity and surface protein abundance by PKB/Akt and PIKfyve.12
232348562012Up-regulation of amino acid transporter SLC6A19 activity and surface protein abundance by PKB/Akt and PIKfyve.12
219642912011Stimulation of the amino acid transporter SLC6A19 by JAK2.3
219642912011Stimulation of the amino acid transporter SLC6A19 by JAK2.3
203993952010Novel mutation in SLC6A19 causing late-onset seizures in Hartnup disorder.8
208835582010Loss of solute carriers in T cell-mediated rejection in mouse and human kidneys: an active epithelial injury-repair response.13
203993952010Novel mutation in SLC6A19 causing late-onset seizures in Hartnup disorder.8

Citation

Dessen P

SLC6A19 (solute carrier family 6 member 19)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53392/slc6a19-(solute-carrier-family-6-member-19)