GAP43 (growth associated protein 43)

2013-06-01  

Identity

HGNC
GAP43
LOCATION
3q13.31
LOCUSID
2596
ALIAS
B-50,GAP-43,PP46
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2596
MIM: 162060
HGNC: 4140
Ensembl: ENSG00000172020

Variants:

dbSNP: 2596
ClinVar: 2596
TCGA: ENSG00000172020
COSMIC: GAP43

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172020ENST00000305124P17677
ENSG00000172020ENST00000305124Q5U058
ENSG00000172020ENST00000393780P17677

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383399282024Associations of Growth-Associated Protein 43 with Cerebral Microbleeds: A Longitudinal Study.0
383399282024Associations of Growth-Associated Protein 43 with Cerebral Microbleeds: A Longitudinal Study.0
367392962023Impact of GAP-43, Cx43 and actin expression on the outcome and overall survival in diffuse and anaplastic gliomas.1
369633472023Growth associated protein 43 deficiency promotes podocyte injury by activating the calmodulin/calcineurin pathway under hyperglycemia.0
371698422023GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity.23
378520452023Association of APOE-ε4 and GAP-43-related presynaptic loss with β-amyloid, tau, neurodegeneration, and cognitive decline.1
367392962023Impact of GAP-43, Cx43 and actin expression on the outcome and overall survival in diffuse and anaplastic gliomas.1
369633472023Growth associated protein 43 deficiency promotes podocyte injury by activating the calmodulin/calcineurin pathway under hyperglycemia.0
371698422023GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity.23
378520452023Association of APOE-ε4 and GAP-43-related presynaptic loss with β-amyloid, tau, neurodegeneration, and cognitive decline.1
352588502022Prognostic value of cutaneous reinnervation with GAP-43 in oxaliplatin-induced neuropathy.1
363835682022Cutaneous expression of growth-associated protein 43 is not a compelling marker for human nerve regeneration in carpal tunnel syndrome.0
366118082022Association of CSF GAP-43 and APOE ε4 with Cognition in Mild Cognitive Impairment and Alzheimer's Disease.3
352588502022Prognostic value of cutaneous reinnervation with GAP-43 in oxaliplatin-induced neuropathy.1
363835682022Cutaneous expression of growth-associated protein 43 is not a compelling marker for human nerve regeneration in carpal tunnel syndrome.0

Citation

Dessen P

GAP43 (growth associated protein 43)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53398/gap43-(growth-associated-protein-43)