ARPC4 (actin related protein 2/3 complex subunit 4)

2013-06-01  

Identity

HGNC
ARPC4
LOCATION
3p25.3
LOCUSID
10093
ALIAS
ARC20,P20-ARC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10093
MIM: 604226
HGNC: 707
Ensembl: ENSG00000241553

Variants:

dbSNP: 10093
ClinVar: 10093
TCGA: ENSG00000241553
COSMIC: ARPC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241553ENST00000397261P59998
ENSG00000241553ENST00000417500F8WDW3
ENSG00000241553ENST00000433034P59998
ENSG00000241553ENST00000440787F8WDD7
ENSG00000241553ENST00000485273R4GN08
ENSG00000241553ENST00000498623P59998

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Pathogenic Escherichia coli infectionKEGGko05130
Regulation of actin cytoskeletonKEGGhsa04810
Pathogenic Escherichia coli infectionKEGGhsa05130
ShigellosisKEGGhsa05131
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

References

Pubmed IDYearTitleCitations
311904012020ARPC4 promotes bladder cancer cell invasion and is associated with lymph node metastasis.11
311904012020ARPC4 promotes bladder cancer cell invasion and is associated with lymph node metastasis.11
232671272013Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration.33
238945632013Expression of the ARPC4 subunit of human Arp2/3 severely affects mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophages.5
232671272013Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration.33
238945632013Expression of the ARPC4 subunit of human Arp2/3 severely affects mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophages.5
172749802007Coronin 3 involvement in F-actin-dependent processes at the cell cortex.25
172749802007Coronin 3 involvement in F-actin-dependent processes at the cell cortex.25

Citation

Dessen P

ARPC4 (actin related protein 2/3 complex subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53405/arpc4-(actin-related-protein-2-3-complex-subunit-4)