HCRTR2 (hypocretin receptor 2)

Identity

HGNC

HCRTR2

LOCATION

6p12.1

LOCUSID

3062

ALIAS

ORXR2,OX2R,OXR2

Other Information

Locus ID:

NCBI: 3062
MIM: 602393
HGNC: 4849
Ensembl: ENSG00000137252

Variants:

dbSNP: 3062
ClinVar: 3062
TCGA: ENSG00000137252
COSMIC: HCRTR2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000137252	ENST00000370862	O43614
ENSG00000137252	ENST00000370862	S4X0W3
ENSG00000137252	ENST00000615358	O43614
ENSG00000137252	ENST00000615358	S4X0W3

Expression (GTEx)

0

1

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
GPCR downstream signaling	REACTOME	R-HSA-388396
GPCR ligand binding	REACTOME	R-HSA-500792
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Orexin and neuropeptides FF and QRFP bind to their respective receptors	REACTOME	R-HSA-389397
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
Signal Transduction	REACTOME	R-HSA-162582

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
30326460	2019	The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms.	6
31768945	2020	Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.	5
31768945	2020	Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.	5
31983458	2020	Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.	4
31983458	2020	Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.	4
33547286	2021	Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.	42
33547286	2021	Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.	42
34472713	2021	Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.	1
34472713	2021	Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.	1
36901420	2023	Relationship between APOE, PER2, PER3 and OX2R Genetic Variants and Neuropsychiatric Symptoms in Patients with Alzheimer's Disease.	1

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Citation

Dessen P

HCRTR2 (hypocretin receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53420