Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 284266
MIM: 618105
HGNC: 27596
Ensembl: ENSG00000197046
Variants:
dbSNP: 284266
ClinVar: 284266
TCGA: ENSG00000197046
COSMIC: SIGLEC15
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000197046 | ENST00000389474 | Q6ZMC9 |
| ENSG00000197046 | ENST00000546268 | Q6ZMC9 |
| ENSG00000197046 | ENST00000587418 | K7EN40 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| DAP12 interactions | REACTOME | R-HSA-2172127 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38072971 | 2024 | Siglec-15 on macrophages suppress the immune microenvironment in patients with PD-L1 negative non-metastasis lung adenocarcinoma. | 2 |
| 38169162 | 2024 | Siglec-15 regulates cell proliferation, migration and invasion in bladder cancer. | 0 |
| 38072971 | 2024 | Siglec-15 on macrophages suppress the immune microenvironment in patients with PD-L1 negative non-metastasis lung adenocarcinoma. | 2 |
| 38169162 | 2024 | Siglec-15 regulates cell proliferation, migration and invasion in bladder cancer. | 0 |
| 36265694 | 2023 | Siglec-15 as multifunctional molecule involved in osteoclast differentiation, cancer immunity and microbial infection. | 2 |
| 36424637 | 2023 | Significance of Siglec-15 expression in colorectal cancer: association with advanced disease stage and fewer tumor-infiltrating lymphocytes. | 0 |
| 36614238 | 2023 | Transcriptional Regulation of Siglec-15 by ETS-1 and ETS-2 in Hepatocellular Carcinoma Cells. | 1 |
| 37129515 | 2023 | Siglec15 promotes the migration of thyroid carcinoma cells by enhancing the EGFR protein stability. | 1 |
| 37234161 | 2023 | Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma. | 1 |
| 37311743 | 2023 | Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b. | 4 |
| 37325664 | 2023 | Siglec15 is a prognostic indicator and a potential tumor-related macrophage regulator that is involved in the suppressive immunomicroenvironment in gliomas. | 1 |
| 37465593 | 2023 | Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia. | 1 |
| 37674198 | 2023 | Non-spatial and spatial heterogeneity revealed a suppressive immune feature of Siglec-15 in lung adenocarcinomas. | 2 |
| 37843557 | 2023 | Siglec 15 as a biomarker or a druggable molecule for non-small cell lung cancer. | 1 |
| 36265694 | 2023 | Siglec-15 as multifunctional molecule involved in osteoclast differentiation, cancer immunity and microbial infection. | 2 |
Citation
Dessen P
SIGLEC15 (sialic acid binding Ig like lectin 15)
Atlas Genet Cytogenet Oncol Haematol. 2013-07-01
Online version: http://atlasgeneticsoncology.org/gene/53430
