BHLHA15 (basic helix-loop-helix family member a15)

2013-07-01  

Identity

HGNC
BHLHA15
LOCATION
7q21.3
LOCUSID
168620
ALIAS
BHLHB8,MIST1

Other Information

Locus ID:

NCBI: 168620
MIM: 608606
HGNC: 22265
Ensembl: ENSG00000180535

Variants:

dbSNP: 168620
ClinVar: 168620
TCGA: ENSG00000180535
COSMIC: BHLHA15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180535ENST00000314018Q7RTS1
ENSG00000180535ENST00000609256Q7RTS1

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Maturity onset diabetes of the youngKEGGko04950
Maturity onset diabetes of the youngKEGGhsa04950

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
207098042010The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma.53
200385312010RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation.46
219077082011The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the Mist.33
166450412006Identification of a basic helix-loop-helix transcription factor expressed in mammary gland alveolar cells and required for maintenance of the differentiated state.12
210986832011Transcription factor MIST1 in terminal differentiation of mouse and human plasma cells.11
298592992018Overexpression of MIST1 reverses the epithelial-mesenchymal transition and reduces the tumorigenicity of pancreatic cancer cells via the Snail/E-cadherin pathway.9
223748152012Activation of protein kinase Cδ leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1.5
203823422010Body mass index and von Hippel-Lindau gene mutations in clear-cell renal cancer: Results of the Netherlands Cohort Study on diet and cancer.2
224953702012MIST1-a novel marker of plasmacytic differentiation.0
307597172019MIST1, an Inductive Signal for Salivary Amylase in Mesenchymal Stem Cells.0

Citation

Dessen P

BHLHA15 (basic helix-loop-helix family member a15)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53455/bhlha15-(basic-helix-loop-helix-family-member-a15)