QPCT (glutaminyl-peptide cyclotransferase)

2013-07-01  

Identity

HGNC
QPCT
LOCATION
2p22.2
LOCUSID
25797
ALIAS
GCT,QC,sQC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25797
MIM: 607065
HGNC: 9753
Ensembl: ENSG00000115828

Variants:

dbSNP: 25797
ClinVar: 25797
TCGA: ENSG00000115828
COSMIC: QPCT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115828ENST00000338415Q16769
ENSG00000115828ENST00000404976B5MCZ9
ENSG00000115828ENST00000444022C9JS14
ENSG00000115828ENST00000650442A0A3B3IUD5

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
pituitary gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370608242023Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer.3
373811752023Apicidin confers promising therapeutic effect on acute myeloid leukemia cells via increasing QPCT expression.1
370608242023Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer.3
373811752023Apicidin confers promising therapeutic effect on acute myeloid leukemia cells via increasing QPCT expression.1
337740342021A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes.1
340363852021QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis.4
343097602021A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies.8
337740342021A Unique Carboxylic-Acid Hydrogen-Bond Network (CAHBN) Confers Glutaminyl Cyclase Activity on M28 Family Enzymes.1
340363852021QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis.4
343097602021A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies.8
325515352020Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer's Disease.3
325515352020Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer's Disease.3
285876592017Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer's disease patients.7
285876592017Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer's disease patients.7
264928382016Common variants in QPCT gene confer risk of schizophrenia in the Han Chinese population.2

Citation

Dessen P

QPCT (glutaminyl-peptide cyclotransferase)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53467/qpct-(glutaminyl-peptide-cyclotransferase)