Identity
HGNC
LOCATION
4q13.1
LOCUSID
ALIAS
CIRL3,CL3,LEC3,LPHN3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23284
MIM: 616417
HGNC: 20974
Ensembl: ENSG00000150471
Variants:
dbSNP: 23284
ClinVar: 23284
TCGA: ENSG00000150471
COSMIC: ADGRL3
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA445876 | Tobacco Use Disorder | Disease | ClinicalAnnotation | associated | PD | ||
| PA447197 | Attention Deficit Disorder with Hyperactivity | Disease | ClinicalAnnotation | associated | PD | 20157310, 22486528, 22851411, 25229170, 25989180, 29230023 | |
| PA450464 | methylphenidate | Chemical | ClinicalAnnotation | associated | PD | 20157310, 22486528, 22851411, 25229170, 25989180, 29230023 | |
| PA450626 | nicotine | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37224017 | 2023 | The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms. | 3 |
| 37224017 | 2023 | The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms. | 3 |
| 34009035 | 2022 | Machine Learning Prediction of ADHD Severity: Association and Linkage to ADGRL3, DRD4, and SNAP25. | 9 |
| 35013530 | 2022 | Driver mutations in ADGRL3 are involved in the evolution of ependymoma. | 3 |
| 35393556 | 2022 | Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility. | 3 |
| 35741042 | 2022 | Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations. | 0 |
| 36151371 | 2022 | ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP. | 1 |
| 34009035 | 2022 | Machine Learning Prediction of ADHD Severity: Association and Linkage to ADGRL3, DRD4, and SNAP25. | 9 |
| 35013530 | 2022 | Driver mutations in ADGRL3 are involved in the evolution of ependymoma. | 3 |
| 35393556 | 2022 | Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility. | 3 |
| 35741042 | 2022 | Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations. | 0 |
| 36151371 | 2022 | ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP. | 1 |
| 32691279 | 2021 | CDH13 and LPHN3 Gene Polymorphisms in Attention-Deficit/Hyperactivity Disorder: Their Relation to Clinical Characteristics. | 2 |
| 32787626 | 2021 | Expression of the adult ADHD-associated gene ADGRL3 is dysregulated by risk variants and environmental risk factors. | 4 |
| 33504901 | 2021 | Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder. | 0 |
Citation
Dessen P
ADGRL3 (adhesion G protein-coupled receptor L3)
Atlas Genet Cytogenet Oncol Haematol. 2013-07-01
Online version: http://atlasgeneticsoncology.org/gene/53471/adgrl3-(adhesion-g-protein-coupled-receptor-l3)
