ADGRL3 (adhesion G protein-coupled receptor L3)

2013-07-01   Dessen P  

Identity

HGNC
ADGRL3
LOCATION
4q13.1
LOCUSID
23284
ALIAS
CIRL3,CL3,LEC3,LPHN3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23284
MIM: 616417
HGNC: 20974
Ensembl: ENSG00000150471

Variants:

dbSNP: 23284
ClinVar: 23284
TCGA: ENSG00000150471
COSMIC: ADGRL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150471ENST00000502815H0Y9K5
ENSG00000150471ENST00000504896E7ENK1
ENSG00000150471ENST00000506700E7EMR3
ENSG00000150471ENST00000506720E7EUW2
ENSG00000150471ENST00000506746E7ETE3
ENSG00000150471ENST00000507164E7EX52
ENSG00000150471ENST00000507625E7EVD6
ENSG00000150471ENST00000508693E7EN28
ENSG00000150471ENST00000508946E7EW95
ENSG00000150471ENST00000509896E7EUP0
ENSG00000150471ENST00000511324E7ESV6
ENSG00000150471ENST00000512091Q9HAR2
ENSG00000150471ENST00000514157E7ES20
ENSG00000150471ENST00000514591Q9HAR2
ENSG00000150471ENST00000514996E9PBG4

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445876Tobacco Use DisorderDiseaseClinicalAnnotationassociatedPD
PA447197Attention Deficit Disorder with HyperactivityDiseaseClinicalAnnotationassociatedPD20157310, 22486528, 22851411, 25229170, 25989180, 29230023
PA450464methylphenidateChemicalClinicalAnnotationassociatedPD20157310, 22486528, 22851411, 25229170, 25989180, 29230023
PA450626nicotineChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
372240172023The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.3
372240172023The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.3
340090352022Machine Learning Prediction of ADHD Severity: Association and Linkage to ADGRL3, DRD4, and SNAP25.9
350135302022Driver mutations in ADGRL3 are involved in the evolution of ependymoma.3
353935562022Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility.3
357410422022Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations.0
361513712022ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP.1
340090352022Machine Learning Prediction of ADHD Severity: Association and Linkage to ADGRL3, DRD4, and SNAP25.9
350135302022Driver mutations in ADGRL3 are involved in the evolution of ependymoma.3
353935562022Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility.3
357410422022Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations.0
361513712022ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIP.1
326912792021CDH13 and LPHN3 Gene Polymorphisms in Attention-Deficit/Hyperactivity Disorder: Their Relation to Clinical Characteristics.2
327876262021Expression of the adult ADHD-associated gene ADGRL3 is dysregulated by risk variants and environmental risk factors.4
335049012021Brain structural and functional substrates of ADGRL3 (latrophilin 3) haplotype in attention-deficit/hyperactivity disorder.0

Citation

Dessen P

ADGRL3 (adhesion G protein-coupled receptor L3)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53471/adgrl3-(adhesion-g-protein-coupled-receptor-l3)