NEDD1 (NEDD1 gamma-tubulin ring complex targeting factor)

2013-07-01  

Identity

HGNC
LOCATION
12q23.1
LOCUSID
ALIAS
GCP-WD,TUBGCP7
FUSION GENES

Other Information

Locus ID:

NCBI: 121441
MIM: 600372
HGNC: 7723
Ensembl: ENSG00000139350

Variants:

dbSNP: 121441
ClinVar: 121441
TCGA: ENSG00000139350
COSMIC: NEDD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139350ENST00000266742Q8NHV4
ENSG00000139350ENST00000266742A0A024RBE5
ENSG00000139350ENST00000411739Q8NHV4
ENSG00000139350ENST00000429527Q8NHV4
ENSG00000139350ENST00000429527A0A024RBE5
ENSG00000139350ENST00000457368Q8NHV4
ENSG00000139350ENST00000553609G3V4I9
ENSG00000139350ENST00000554226G3V2V3
ENSG00000139350ENST00000555806G3V2S2
ENSG00000139350ENST00000557092G3V2M9
ENSG00000139350ENST00000557478G3V4L2
ENSG00000139350ENST00000557644Q8NHV4

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Recruitment of NuMA to mitotic centrosomesREACTOMER-HSA-380320
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
363181152022NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis.3
363181152022NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis.3
333511002021PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations.6
333511002021PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations.6
310281802019Microtubule nucleation during central spindle assembly requires NEDD1 phosphorylation on serine 405 by Aurora A.9
310281802019Microtubule nucleation during central spindle assembly requires NEDD1 phosphorylation on serine 405 by Aurora A.9
231067872013Intraperitoneal delivery of a small interfering RNA targeting NEDD1 prolongs the survival of scirrhous gastric cancer model mice.9
232738982013The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function.30
231067872013Intraperitoneal delivery of a small interfering RNA targeting NEDD1 prolongs the survival of scirrhous gastric cancer model mice.9
232738982013The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function.30
225955252012Novel NEDD1 phosphorylation sites regulate γ-tubulin binding and mitotic spindle assembly.21
228189142012Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.41
225955252012Novel NEDD1 phosphorylation sites regulate γ-tubulin binding and mitotic spindle assembly.21
228189142012Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.41
202247772010A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome.19

Citation

Dessen P

NEDD1 (NEDD1 gamma-tubulin ring complex targeting factor)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53473/nedd1-(nedd1-gamma-tubulin-ring-complex-targeting-factor)