SIRT5 (sirtuin 5)

2013-08-01  

Identity

HGNC
LOCATION
6p23
LOCUSID
ALIAS
SIR2L5

Other Information

Locus ID:

NCBI: 23408
MIM: 604483
HGNC: 14933
Ensembl: ENSG00000124523

Variants:

dbSNP: 23408
ClinVar: 23408
TCGA: ENSG00000124523
COSMIC: SIRT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124523ENST00000359782Q9NXA8
ENSG00000124523ENST00000379250Q7Z3A0
ENSG00000124523ENST00000379262Q9NXA8
ENSG00000124523ENST00000397350Q9NXA8
ENSG00000124523ENST00000606117Q9NXA8
ENSG00000124523ENST00000606117A0A024R012
ENSG00000124523ENST00000606427U3KQT8

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
220763782011Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.376
219087712011The first identification of lysine malonylation substrates and its regulatory enzyme.216
186807532008Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.191
257171142015Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.90
234756222013Altered expression of SIRT gene family in head and neck squamous cell carcinoma.48
241400622013SIRT5 desuccinylates and activates SOD1 to eliminate ROS.44
250704882014SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer.43
208877902011Brain molecular aging, promotion of neurological disease and modulation by sirtuin 5 longevity gene polymorphism.38
271640522016The role of mitochondrial sirtuins in health and disease.36
271137622016SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense.30

Citation

Dessen P

SIRT5 (sirtuin 5)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53478/sirt5-(sirtuin-5)