Identity
HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
C10orf42,CCDC109A,HsMCU
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 90550
MIM: 614197
HGNC: 23526
Ensembl: ENSG00000156026
Variants:
dbSNP: 90550
ClinVar: 90550
TCGA: ENSG00000156026
COSMIC: MCU
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Calcium signaling pathway | KEGG | ko04020 |
| Calcium signaling pathway | KEGG | hsa04020 |
| NOD-like receptor signaling pathway | KEGG | ko04621 |
| NOD-like receptor signaling pathway | KEGG | hsa04621 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37702230 | 2024 | Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1. | 2 |
| 38599304 | 2024 | Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca(2+) uptake and viability. | 1 |
| 38763207 | 2024 | MCU inhibition protects against intestinal ischemia‒reperfusion by inhibiting Drp1-dependent mitochondrial fission. | 0 |
| 37702230 | 2024 | Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1. | 2 |
| 38599304 | 2024 | Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca(2+) uptake and viability. | 1 |
| 38763207 | 2024 | MCU inhibition protects against intestinal ischemia‒reperfusion by inhibiting Drp1-dependent mitochondrial fission. | 0 |
| 37302345 | 2023 | The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state. | 1 |
| 38007529 | 2023 | Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis. | 5 |
| 37302345 | 2023 | The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state. | 1 |
| 38007529 | 2023 | Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis. | 5 |
| 34847839 | 2022 | Dihydroartemisinin represses oral squamous cell carcinoma progression through downregulating mitochondrial calcium uniporter. | 7 |
| 35413105 | 2022 | Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer. | 26 |
| 34847839 | 2022 | Dihydroartemisinin represses oral squamous cell carcinoma progression through downregulating mitochondrial calcium uniporter. | 7 |
| 35413105 | 2022 | Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer. | 26 |
| 32862359 | 2021 | Structure of intact human MCU supercomplex with the auxiliary MICU subunits. | 27 |
Citation
Dessen P
MCU (mitochondrial calcium uniporter)
Atlas Genet Cytogenet Oncol Haematol. 2013-08-01
Online version: http://atlasgeneticsoncology.org/gene/53485/mcu-(mitochondrial-calcium-uniporter)
