HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1)

2013-08-01 Affiliation

Identity

HGNC

HERPUD1

LOCATION

16q13

LOCUSID

9709

ALIAS

HERP,Mif1,SUP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9709
MIM: 608070
HGNC: 13744
Ensembl: ENSG00000051108

Variants:

dbSNP: 9709
ClinVar: 9709
TCGA: ENSG00000051108
COSMIC: HERPUD1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000051108	ENST00000300302	Q15011
ENSG00000051108	ENST00000344114	Q15011
ENSG00000051108	ENST00000379792	Q15011
ENSG00000051108	ENST00000439977	Q15011
ENSG00000051108	ENST00000563343	H3BP08
ENSG00000051108	ENST00000563911	H3BQM2
ENSG00000051108	ENST00000565966	H3BRS4
ENSG00000051108	ENST00000568358	H3BTA8
ENSG00000051108	ENST00000568651	H3BV54
ENSG00000051108	ENST00000569429	H3BTT7

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
HRD1/SEL1 ERAD complex	KEGG	hsa_M00403
HRD1/SEL1 ERAD complex	KEGG	M00403
Metabolism of proteins	REACTOME	R-HSA-392499
Unfolded Protein Response (UPR)	REACTOME	R-HSA-381119
PERK regulates gene expression	REACTOME	R-HSA-381042
ATF4 activates genes	REACTOME	R-HSA-380994

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18042451	2007	Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp.	96
16940180	2006	Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element.	52
18307982	2008	Herp enhances ER-associated protein degradation by recruiting ubiquilins.	37
11799129	2002	Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein.	23
21149444	2011	Herp regulates Hrd1-mediated ubiquitylation in a ubiquitin-like domain-dependent manner.	22
19447887	2009	The homocysteine-inducible endoplasmic reticulum stress protein counteracts calcium store depletion and induction of CCAAT enhancer-binding protein homologous protein in a neurotoxin model of Parkinson disease.	18
19788048	2009	Homocysteine-induced endoplasmic reticulum protein (herp) is up-regulated in parkinsonian substantia nigra and present in the core of Lewy bodies.	16
14550564	2003	The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amyloid beta-protein generation.	15
29295953	2018	The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation.	12
25637874	2015	Induction of Herpud1 expression by ER stress is regulated by Nrf1.	11

Citation

Dessen P

HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53491/herpud1-(homocysteine-inducible-er-protein-with-ubiquitin-like-domain-1)