H1-5 (H1.5 linker histone, cluster member)

2013-09-01  

Identity

HGNC
H1-5
LOCATION
6p22.1
LOCUSID
3009
ALIAS
H1,H1.5,H1B,H1F5,H1s-3,HIST1H1B

Other Information

Locus ID:

NCBI: 3009
MIM: 142711
HGNC: 4719
Ensembl: ENSG00000184357

Variants:

dbSNP: 3009
ClinVar: 3009
TCGA: ENSG00000184357
COSMIC: H1-5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184357ENST00000331442P16401

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptosis induced DNA fragmentationREACTOMER-HSA-140342
Activation of DNA fragmentation factorREACTOMER-HSA-211227
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584

References

Pubmed IDYearTitleCitations
244350472014Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.58
155957312004Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry.46
163776192006Histone H1 phosphorylation occurs site-specifically during interphase and mitosis: identification of a novel phosphorylation site on histone H1.40
161850662005Linker histone H1 per se can induce three-dimensional folding of chromatin fiber.18
191360082009M phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3.14
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
216548452011FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity.9
234160302013Promyelocytic leukemia zinc finger and histone H1.5 differentially stain low- and high-grade pulmonary neuroendocrine tumors: a pilot immunohistochemical study.6
247847182014Immunohistochemical detection of promyelocytic leukemia zinc finger and histone 1.5 in uterine leiomyosarcoma and leiomyoma.1
310767402019Histone H1.5 binds over splice sites in chromatin and regulates alternative splicing.1

Citation

Dessen P

H1-5 (H1.5 linker histone, cluster member)

Atlas Genet Cytogenet Oncol Haematol. 2013-09-01

Online version: http://atlasgeneticsoncology.org/gene/53525/h1-5-(h1-5-linker-histone-cluster-member)