Identity
HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
ACHRA,ACHRD,CHRNA,CMS1A,CMS1B,CMS2A,FCCMS,SCCMS
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1134
MIM: 100690
HGNC: 1955
Ensembl: ENSG00000138435
Variants:
dbSNP: 1134
ClinVar: 1134
TCGA: ENSG00000138435
COSMIC: CHRNA1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA133950441 | hmg coa reductase inhibitors | Chemical | VariantAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33476802 | 2021 | CHRNA1 promotes the pathogenesis of primary focal hyperhidrosis. | 7 |
| 33652901 | 2021 | Point Mutations of Nicotinic Receptor α1 Subunit Reveal New Molecular Features of G153S Slow-Channel Myasthenia. | 2 |
| 33476802 | 2021 | CHRNA1 promotes the pathogenesis of primary focal hyperhidrosis. | 7 |
| 33652901 | 2021 | Point Mutations of Nicotinic Receptor α1 Subunit Reveal New Molecular Features of G153S Slow-Channel Myasthenia. | 2 |
| 31855720 | 2020 | Increased serum acetylcholine receptor α1 subunit protein in anti-acetylcholine receptor antibody-positive myasthenia gravis. | 1 |
| 31855720 | 2020 | Increased serum acetylcholine receptor α1 subunit protein in anti-acetylcholine receptor antibody-positive myasthenia gravis. | 1 |
| 29688589 | 2018 | Evaluating the effect of nicotinic cholinergic receptor genes on the risk of nonsyndromic cleft lip with or without cleft palate. | 0 |
| 29688589 | 2018 | Evaluating the effect of nicotinic cholinergic receptor genes on the risk of nonsyndromic cleft lip with or without cleft palate. | 0 |
| 26656837 | 2016 | Effect of nicotinic acetylcholine receptor alpha 1 (nAChRα1) peptides on rabies virus infection in neuronal cells. | 2 |
| 27649498 | 2016 | High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor. | 4 |
| 26656837 | 2016 | Effect of nicotinic acetylcholine receptor alpha 1 (nAChRα1) peptides on rabies virus infection in neuronal cells. | 2 |
| 27649498 | 2016 | High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor. | 4 |
| 25279974 | 2015 | Role of SLCO1B1, ABCB1, and CHRNA1 gene polymorphisms on the efficacy of rocuronium in Chinese patients. | 8 |
| 25670150 | 2015 | Nicotine induces resistance to erlotinib via cross-talk between α 1 nAChR and EGFR in the non-small cell lung cancer xenograft model. | 17 |
| 25888793 | 2015 | Antisense oligonucleotide-mediated exon skipping of CHRNA1 pre-mRNA as potential therapy for Congenital Myasthenic Syndromes. | 9 |
Citation
Dessen P
CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit)
Atlas Genet Cytogenet Oncol Haematol. 2013-09-01
Online version: http://atlasgeneticsoncology.org/gene/53528/chrna1-(cholinergic-receptor-nicotinic-alpha-1-subunit)
