CD320 (CD320 molecule)

2013-12-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
8D6,8D6A,TCBLR,TCN2R
FUSION GENES

Other Information

Locus ID:

NCBI: 51293
MIM: 606475
HGNC: 16692
Ensembl: ENSG00000167775

Variants:

dbSNP: 51293
ClinVar: 51293
TCGA: ENSG00000167775
COSMIC: CD320

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167775ENST00000301458Q9NPF0
ENSG00000167775ENST00000537716Q9NPF0
ENSG00000167775ENST00000596002M0R1C4
ENSG00000167775ENST00000599573M0R100

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of metabolismREACTOMER-HSA-5668914
Defects in vitamin and cofactor metabolismREACTOMER-HSA-3296482
Defects in cobalamin (B12) metabolismREACTOMER-HSA-3296469
Defective CD320 causes methylmalonic aciduriaREACTOMER-HSA-3359485
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Cobalamin (Cbl, vitamin B12) transport and metabolismREACTOMER-HSA-196741

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
372020782023Transcobalamin receptor gene polymorphisms and mutation in an elderly population.0
372020782023Transcobalamin receptor gene polymorphisms and mutation in an elderly population.0
351072112022Probing the functional consequence and clinical relevance of CD320 p.E88del, a variant in the transcobalamin receptor gene.2
351072112022Probing the functional consequence and clinical relevance of CD320 p.E88del, a variant in the transcobalamin receptor gene.2
338030252021Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter.3
338030252021Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter.3
3249842920203'-UTR Polymorphisms of Vitamin B-Related Genes Are Associated with Osteoporosis and Osteoporotic Vertebral Compression Fractures (OVCFs) in Postmenopausal Women.7
328985522020Cellular uptake of vitamin B(12): Role and fate of TCblR/CD320, the transcobalamin receptor.10
3249842920203'-UTR Polymorphisms of Vitamin B-Related Genes Are Associated with Osteoporosis and Osteoporotic Vertebral Compression Fractures (OVCFs) in Postmenopausal Women.7
328985522020Cellular uptake of vitamin B(12): Role and fate of TCblR/CD320, the transcobalamin receptor.10
311239542019Genetic polymorphisms of the cobalamin transport system are associated with idiopathic recurrent implantation failure.1
311239542019Genetic polymorphisms of the cobalamin transport system are associated with idiopathic recurrent implantation failure.1
295373282018Evaluation of transcobalamin II rs1801198 and transcobalamin II receptor rs2336573 gene polymorphisms in recurrent spontaneous abortion.1
296636332018Transcobalamin receptor defect: Identification of two new cases through positive newborn screening for propionic/methylmalonic aciduria and long-term outcome.4
295373282018Evaluation of transcobalamin II rs1801198 and transcobalamin II receptor rs2336573 gene polymorphisms in recurrent spontaneous abortion.1

Citation

Dessen P

CD320 (CD320 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2013-12-01

Online version: http://atlasgeneticsoncology.org/gene/53536/cd320-(cd320-molecule)