SLC7A7 (solute carrier family 7 member 7)

2013-11-01  

Identity

HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
LAT3,LPI,MOP-2,Y+LAT1,y+LAT-1
FUSION GENES

Other Information

Locus ID:

NCBI: 9056
MIM: 603593
HGNC: 11065
Ensembl: ENSG00000155465

Variants:

dbSNP: 9056
ClinVar: 9056
TCGA: ENSG00000155465
COSMIC: SLC7A7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155465ENST00000285850Q9UM01
ENSG00000155465ENST00000285850A0A0S2Z502
ENSG00000155465ENST00000397528Q9UM01
ENSG00000155465ENST00000397528A0A0S2Z502
ENSG00000155465ENST00000397529Q9UM01
ENSG00000155465ENST00000397529A0A0S2Z502
ENSG00000155465ENST00000397532Q9UM01
ENSG00000155465ENST00000397532A0A0S2Z502
ENSG00000155465ENST00000488800D6RFE5
ENSG00000155465ENST00000554517G3V4Z6
ENSG00000155465ENST00000554741G3V362
ENSG00000155465ENST00000554758G3V2H8
ENSG00000155465ENST00000555251G3V4U1
ENSG00000155465ENST00000555702Q9UM01
ENSG00000155465ENST00000555702A0A0S2Z502
ENSG00000155465ENST00000555911G3V5W2
ENSG00000155465ENST00000555959G3V5A1
ENSG00000155465ENST00000556287G3V2K0
ENSG00000155465ENST00000556350H0YJ95
ENSG00000155465ENST00000557129G3V2L0
ENSG00000155465ENST00000557629G3V273
ENSG00000155465ENST00000674313A0A0S2Z502

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
334369542021L-type amino acid transporter 1 is associated with chemoresistance in breast cancer via the promotion of amino acid metabolism.24
334369542021L-type amino acid transporter 1 is associated with chemoresistance in breast cancer via the promotion of amino acid metabolism.24
317056282020y+LAT1 and y+LAT2 contribution to arginine uptake in different human cell models: Implications in the pathophysiology of Lysinuric Protein Intolerance.19
325040802020A global Slc7a7 knockout mouse model demonstrates characteristic phenotypes of human lysinuric protein intolerance.9
317056282020y+LAT1 and y+LAT2 contribution to arginine uptake in different human cell models: Implications in the pathophysiology of Lysinuric Protein Intolerance.19
325040802020A global Slc7a7 knockout mouse model demonstrates characteristic phenotypes of human lysinuric protein intolerance.9
308326862019Analysis of LPI-causing mutations on y+LAT1 function and localization.6
310144322019[Clinical features of children with lysinuric protein intolerance and SLC7A7 gene mutation: an analysis of 3 cases].2
308326862019Analysis of LPI-causing mutations on y+LAT1 function and localization.6
310144322019[Clinical features of children with lysinuric protein intolerance and SLC7A7 gene mutation: an analysis of 3 cases].2
294996432018Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia.38
296160262018Downregulation of SLC7A7 Triggers an Inflammatory Phenotype in Human Macrophages and Airway Epithelial Cells.16
300253932018Function of SLC7A7 in T-Cell Acute Lymphoblastic Leukemia.5
294996432018Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia.38
296160262018Downregulation of SLC7A7 Triggers an Inflammatory Phenotype in Human Macrophages and Airway Epithelial Cells.16

Citation

Dessen P

SLC7A7 (solute carrier family 7 member 7)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53539/chromosome-explorer/gene-explorer/