Identity
HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
OASL1,OASLd,TRIP-14,TRIP14,p59
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8638
MIM: 603281
HGNC: 8090
Ensembl: ENSG00000135114
Variants:
dbSNP: 8638
ClinVar: 8638
TCGA: ENSG00000135114
COSMIC: OASL
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000135114 | ENST00000257570 | Q15646 |
| ENSG00000135114 | ENST00000339275 | Q15646 |
| ENSG00000135114 | ENST00000543677 | H0YGP3 |
| ENSG00000135114 | ENST00000620239 | Q15646 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164784024 | peginterferon alfa-2b | Chemical | ClinicalAnnotation | associated | PD | 21993426 | |
| PA444445 | Hepatitis C | Disease | ClinicalAnnotation | associated | PD | 21993426 | |
| PA451241 | ribavirin | Chemical | ClinicalAnnotation | associated | PD | 21993426 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38353288 | 2024 | Peptidase inhibitor 16 promotes proliferation of pancreatic ductal adenocarcinoma cells through OASL signaling. | 0 |
| 38353288 | 2024 | Peptidase inhibitor 16 promotes proliferation of pancreatic ductal adenocarcinoma cells through OASL signaling. | 0 |
| 31855809 | 2020 | 2'-5'-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion. | 8 |
| 31855809 | 2020 | 2'-5'-Oligoadenylate synthetase-like protein inhibits intracellular M. tuberculosis replication and promotes proinflammatory cytokine secretion. | 8 |
| 30635239 | 2019 | Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production. | 53 |
| 30635239 | 2019 | Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production. | 53 |
| 27190175 | 2016 | STING-Dependent 2'-5' Oligoadenylate Synthetase-Like Production Is Required for Intracellular Mycobacterium leprae Survival. | 26 |
| 27190175 | 2016 | STING-Dependent 2'-5' Oligoadenylate Synthetase-Like Production Is Required for Intracellular Mycobacterium leprae Survival. | 26 |
| 26178980 | 2015 | 2'-5'-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1. | 22 |
| 26178980 | 2015 | 2'-5'-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1. | 22 |
| 24328427 | 2014 | Differential upregulation of human 2'5'OAS genes on systemic sclerosis: Detection of increased basal levels of OASL and OAS2 genes through a qPCR based assay. | 8 |
| 24931123 | 2014 | Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. | 135 |
| 24328427 | 2014 | Differential upregulation of human 2'5'OAS genes on systemic sclerosis: Detection of increased basal levels of OASL and OAS2 genes through a qPCR based assay. | 8 |
| 24931123 | 2014 | Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. | 135 |
| 23306614 | 2013 | Cancer upregulated gene 2, a novel oncogene, confers resistance to oncolytic vesicular stomatitis virus through STAT1-OASL2 signaling. | 10 |
Citation
Dessen P
OASL (2-5-oligoadenylate synthetase like)
Atlas Genet Cytogenet Oncol Haematol. 2013-11-01
Online version: http://atlasgeneticsoncology.org/gene/53545/
