Identity
HGNC
LOCATION
3p22.1
LOCUSID
ALIAS
CC-CKR-8,CCR-8,CDw198,CKRL1,CMKBR8,CMKBRL2,CY6,GPRCY6,TER1
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1237
MIM: 601834
HGNC: 1609
Ensembl: ENSG00000179934
Variants:
dbSNP: 1237
ClinVar: 1237
TCGA: ENSG00000179934
COSMIC: CCR8
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000179934 | ENST00000326306 | P51685 |
| ENSG00000179934 | ENST00000414803 | C9JIP9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38231448 | 2024 | Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells. | 1 |
| 38306437 | 2024 | Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8. | 1 |
| 38231448 | 2024 | Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells. | 1 |
| 38306437 | 2024 | Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8. | 1 |
| 35041514 | 2022 | Chemokine CCL18 Promotes Phagocytosis Through Its Receptor CCR8 Rather than PITPNM3 in Human Microglial Cells. | 0 |
| 35140181 | 2022 | CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory. | 50 |
| 36352891 | 2022 | Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody. | 5 |
| 35041514 | 2022 | Chemokine CCL18 Promotes Phagocytosis Through Its Receptor CCR8 Rather than PITPNM3 in Human Microglial Cells. | 0 |
| 35140181 | 2022 | CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory. | 50 |
| 36352891 | 2022 | Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody. | 5 |
| 33460563 | 2021 | Chemokine (C-C Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway. | 12 |
| 34025655 | 2021 | Immunomodulation of T Helper Cells by Tumor Microenvironment in Oral Cancer Is Associated With CCR8 Expression and Rapid Membrane Vitamin D Signaling Pathway. | 9 |
| 33460563 | 2021 | Chemokine (C-C Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway. | 12 |
| 34025655 | 2021 | Immunomodulation of T Helper Cells by Tumor Microenvironment in Oral Cancer Is Associated With CCR8 Expression and Rapid Membrane Vitamin D Signaling Pathway. | 9 |
| 32319143 | 2020 | ARNT-dependent CCR8 reprogrammed LDH isoform expression correlates with poor clinical outcomes of prostate cancer. | 4 |
Citation
Dessen P
CCR8 (C-C motif chemokine receptor 8)
Atlas Genet Cytogenet Oncol Haematol. 2013-11-01
Online version: http://atlasgeneticsoncology.org/gene/53548/ccr8-(c-c-motif-chemokine-receptor-8)
