Identity
HGNC
LOCATION
1p21.3
LOCUSID
ALIAS
PTBLP,brPTB,nPTB
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 58155
MIM: 608449
HGNC: 17662
Ensembl: ENSG00000117569
Variants:
dbSNP: 58155
ClinVar: 58155
TCGA: ENSG00000117569
COSMIC: PTBP2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000117569 | ENST00000370197 | Q9UKA9 |
| ENSG00000117569 | ENST00000370198 | Q9UKA9 |
| ENSG00000117569 | ENST00000426398 | Q9UKA9 |
| ENSG00000117569 | ENST00000609116 | Q9UKA9 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38597390 | 2024 | KIS counteracts PTBP2 and regulates alternative exon usage in neurons. | 1 |
| 38597390 | 2024 | KIS counteracts PTBP2 and regulates alternative exon usage in neurons. | 1 |
| 37149717 | 2023 | Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching. | 7 |
| 37149717 | 2023 | Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching. | 7 |
| 35295960 | 2022 | Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants. | 0 |
| 35295960 | 2022 | Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants. | 0 |
| 34459124 | 2021 | LncRNA nuclear-enriched abundant transcript 1 shuttled by prostate cancer cells-secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR-205-5p/runt-related transcription factor 2/splicing factor proline- and glutamine-rich/polypyrimidine tract-binding protein 2 axis. | 27 |
| 34548489 | 2021 | SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity. | 21 |
| 34459124 | 2021 | LncRNA nuclear-enriched abundant transcript 1 shuttled by prostate cancer cells-secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR-205-5p/runt-related transcription factor 2/splicing factor proline- and glutamine-rich/polypyrimidine tract-binding protein 2 axis. | 27 |
| 34548489 | 2021 | SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity. | 21 |
| 30726713 | 2019 | PTBP2 exon 10 inclusion is associated with the progression of CML and it is BCR-ABL1 dependent. | 1 |
| 30726713 | 2019 | PTBP2 exon 10 inclusion is associated with the progression of CML and it is BCR-ABL1 dependent. | 1 |
| 26657638 | 2016 | Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol. | 9 |
| 27681424 | 2016 | PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons. | 39 |
| 26657638 | 2016 | Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol. | 9 |
Citation
Dessen P
PTBP2 (polypyrimidine tract binding protein 2)
Atlas Genet Cytogenet Oncol Haematol. 2013-11-01
Online version: http://atlasgeneticsoncology.org/gene/53551/ptbp2-(polypyrimidine-tract-binding-protein-2)
