Identity
HGNC
LOCATION
13q21.33
LOCUSID
ALIAS
2810028N01Rik,EXOSC11,KIAA1008,RRP44,dis3p
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 22894
MIM: 607533
HGNC: 20604
Ensembl: ENSG00000083520
Variants:
dbSNP: 22894
ClinVar: 22894
TCGA: ENSG00000083520
COSMIC: DIS3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000083520 | ENST00000377767 | Q9Y2L1 |
| ENSG00000083520 | ENST00000377780 | Q9Y2L1 |
| ENSG00000083520 | ENST00000490646 | F2Z2C0 |
| ENSG00000083520 | ENST00000545453 | G3V1J5 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37439377 | 2024 | DIS3 depletion in multiple myeloma causes extensive perturbation in cell cycle progression and centrosome amplification. | 2 |
| 37439377 | 2024 | DIS3 depletion in multiple myeloma causes extensive perturbation in cell cycle progression and centrosome amplification. | 2 |
| 36835493 | 2023 | DIS3: The Enigmatic Gene in Multiple Myeloma. | 4 |
| 36869713 | 2023 | DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis. | 0 |
| 36835493 | 2023 | DIS3: The Enigmatic Gene in Multiple Myeloma. | 4 |
| 36869713 | 2023 | DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis. | 0 |
| 33951891 | 2022 | DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome. | 10 |
| 35394705 | 2022 | MicroRNA-125a/b-5p promotes malignant behavior in multiple myeloma cells and xenograft tumor growth by targeting DIS3. | 0 |
| 35902094 | 2022 | MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of MTR4-sensitive substrates in the human nucleus. | 2 |
| 36215697 | 2022 | Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism. | 7 |
| 33951891 | 2022 | DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome. | 10 |
| 35394705 | 2022 | MicroRNA-125a/b-5p promotes malignant behavior in multiple myeloma cells and xenograft tumor growth by targeting DIS3. | 0 |
| 35902094 | 2022 | MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of MTR4-sensitive substrates in the human nucleus. | 2 |
| 36215697 | 2022 | Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism. | 7 |
| 34059908 | 2021 | RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis. | 6 |
Citation
Dessen P
DIS3 (DIS3 homolog, exosome endoribonuclease and 3-5 exoribonuclease)
Atlas Genet Cytogenet Oncol Haematol. 2014-01-01
Online version: http://atlasgeneticsoncology.org/gene/53556/case-report-explorer/new-content/
