Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1717
MIM: 602858
HGNC: 2860
Ensembl: ENSG00000172893
Variants:
dbSNP: 1717
ClinVar: 1717
TCGA: ENSG00000172893
COSMIC: DHCR7
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166160055 | cholic acid | Chemical | LabelAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38211648 | 2024 | DHCR7 promotes lymph node metastasis in cervical cancer through cholesterol reprogramming-mediated activation of the KANK4/PI3K/AKT axis and VEGF-C secretion. | 0 |
| 38472233 | 2024 | Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis. | 2 |
| 38211648 | 2024 | DHCR7 promotes lymph node metastasis in cervical cancer through cholesterol reprogramming-mediated activation of the KANK4/PI3K/AKT axis and VEGF-C secretion. | 0 |
| 38472233 | 2024 | Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis. | 2 |
| 36182074 | 2023 | Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection. | 1 |
| 36710342 | 2023 | Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer. | 5 |
| 36182074 | 2023 | Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection. | 1 |
| 36710342 | 2023 | Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer. | 5 |
| 32938288 | 2022 | Genetic variants of vitamin D metabolism-related DHCR7/NADSYN1 locus and CYP2R1 gene are associated with clinical features of Parkinson's disease. | 2 |
| 36164611 | 2022 | High DHCR7 Expression Predicts Poor Prognosis for Cervical Cancer. | 4 |
| 32938288 | 2022 | Genetic variants of vitamin D metabolism-related DHCR7/NADSYN1 locus and CYP2R1 gene are associated with clinical features of Parkinson's disease. | 2 |
| 36164611 | 2022 | High DHCR7 Expression Predicts Poor Prognosis for Cervical Cancer. | 4 |
| 33961971 | 2021 | Vitamin D pathway gene polymorphisms, vitamin D level, and cytokines in children with type 1 diabetes. | 11 |
| 34093899 | 2021 | Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis. | 6 |
| 33961971 | 2021 | Vitamin D pathway gene polymorphisms, vitamin D level, and cytokines in children with type 1 diabetes. | 11 |
Citation
Dessen P
DHCR7 (7-dehydrocholesterol reductase)
Atlas Genet Cytogenet Oncol Haematol. 2013-11-01
Online version: http://atlasgeneticsoncology.org/gene/53560/dhcr7-(7-dehydrocholesterol-reductase)
