HOMER3 (homer scaffold protein 3)

2013-11-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
HOMER-3,VESL3
FUSION GENES

Other Information

Locus ID:

NCBI: 9454
MIM: 604800
HGNC: 17514
Ensembl: ENSG00000051128

Variants:

dbSNP: 9454
ClinVar: 9454
TCGA: ENSG00000051128
COSMIC: HOMER3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000051128ENST00000221222Q9NSC5
ENSG00000051128ENST00000392351Q9NSC5
ENSG00000051128ENST00000433218Q9NSC5
ENSG00000051128ENST00000539827Q9NSC5
ENSG00000051128ENST00000542541Q9NSC5
ENSG00000051128ENST00000594439Q9NSC5
ENSG00000051128ENST00000594794M0QYF9
ENSG00000051128ENST00000596482M0R2U7
ENSG00000051128ENST00000599097M0R2T8
ENSG00000051128ENST00000600077M0QZN1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
FoxO signaling pathwayKEGGhsa04068
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382664592024HOMER3 promotes liver hepatocellular carcinoma cancer progression by -upregulating EZH2 and mediating miR-361/GPNMB axis.0
382664592024HOMER3 promotes liver hepatocellular carcinoma cancer progression by -upregulating EZH2 and mediating miR-361/GPNMB axis.0
334077652021HOMER3 facilitates growth factor-mediated β-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer.9
341080142021Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer.13
334077652021HOMER3 facilitates growth factor-mediated β-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer.9
341080142021Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer.13
257394532015Homer3 regulates the establishment of neutrophil polarity.14
257394532015Homer3 regulates the establishment of neutrophil polarity.14
247929072014Calcium regulates the interaction of amyloid precursor protein with Homer3 protein.8
247929072014Calcium regulates the interaction of amyloid precursor protein with Homer3 protein.8
237251682013Growth and differentiation effects of Homer3 on a leukemia cell line.4
237251682013Growth and differentiation effects of Homer3 on a leukemia cell line.4
206934252010Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3.3
206934252010Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3.3
182189012008NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.43

Citation

Dessen P

HOMER3 (homer scaffold protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53566/homer3-(homer-scaffold-protein-3)