ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4)

2013-11-01  

Identity

HGNC
ITIH4
LOCATION
3p21.1
LOCUSID
3700
ALIAS
GP120,H4P,IHRP,ITI-HC4,ITIHL1,PK-120,PK120
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3700
MIM: 600564
HGNC: 6169
Ensembl: ENSG00000055955

Variants:

dbSNP: 3700
ClinVar: 3700
TCGA: ENSG00000055955
COSMIC: ITIH4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000055955ENST00000266041Q14624
ENSG00000055955ENST00000406595Q14624
ENSG00000055955ENST00000441637H7C0L5
ENSG00000055955ENST00000485816B7ZKJ8

Expression (GTEx)

0
500
1000
1500
2000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382898732024Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis.0
382898732024Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis.0
367252502023Longitudinal change of serum inter-alpha-trypsin inhibitor heavy chain H4, and its correlation with inflammation, multiorgan injury, and death risk in sepsis.3
368410322023PGK1 modulates balance between pro- and anti-inflammatory cytokines by interacting with ITI-H4.2
373350612023Hyperglycosylated N-Linked Site 339 of gp120 Appears to Be Unique and May Contribute to CRF01_AE Transmission Among Men Who Have Sex with Men in China and Thailand.0
381568242023Serum interα-trypsin inhibitor heavy chain H4 may be an anti-inflammatory marker reflecting disease risk, activity and treatment outcome of ankylosing spondylitis.0
367252502023Longitudinal change of serum inter-alpha-trypsin inhibitor heavy chain H4, and its correlation with inflammation, multiorgan injury, and death risk in sepsis.3
368410322023PGK1 modulates balance between pro- and anti-inflammatory cytokines by interacting with ITI-H4.2
373350612023Hyperglycosylated N-Linked Site 339 of gp120 Appears to Be Unique and May Contribute to CRF01_AE Transmission Among Men Who Have Sex with Men in China and Thailand.0
381568242023Serum interα-trypsin inhibitor heavy chain H4 may be an anti-inflammatory marker reflecting disease risk, activity and treatment outcome of ankylosing spondylitis.0
342472002022Associations between KCNQ1 and ITIH4 gene polymorphisms and infant weight gain in early life.0
368918812022Serum ITIH4 in coronary heart disease: a potential anti-inflammatory biomarker related to stenosis degree and risk of major adverse cardiovascular events.3
342472002022Associations between KCNQ1 and ITIH4 gene polymorphisms and infant weight gain in early life.0
368918812022Serum ITIH4 in coronary heart disease: a potential anti-inflammatory biomarker related to stenosis degree and risk of major adverse cardiovascular events.3
332380472021Citrullinated inter-alpha-trypsin inhibitor heavy chain 4 in arthritic joints and its potential effect in the neutrophil migration.5

Citation

Dessen P

ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53598/itih4-(inter-alpha-trypsin-inhibitor-heavy-chain-4)