P2RY12 (purinergic receptor P2Y12)

2013-11-01 Affiliation

Identity

HGNC

P2RY12

LOCATION

3q25.1

LOCUSID

64805

ALIAS

ADPG-R,BDPLT8,HORK3,P2T(AC),P2Y(12)R,P2Y(AC),P2Y(ADP),P2Y(cyc),P2Y12,SP1999

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 64805
MIM: 600515
HGNC: 18124
Ensembl: ENSG00000169313

Variants:

dbSNP: 64805
ClinVar: 64805
TCGA: ENSG00000169313
COSMIC: P2RY12

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000169313	ENST00000302632	Q9H244

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Platelet activation	KEGG	hsa04611
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Signal amplification	REACTOME	R-HSA-392518
ADP signalling through P2Y purinoceptor 12	REACTOME	R-HSA-392170
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Nucleotide-like (purinergic) receptors	REACTOME	R-HSA-418038
P2Y receptors	REACTOME	R-HSA-417957
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA154410481	prasugrel	Chemical	Literature, MultilinkAnnotation, Pathway	associated		20938371, 24951432
PA165108401	Acute coronary syndrome	Disease	ClinicalAnnotation	associated	PD	12912815, 14662702, 15795539, 16181985, 16405973, 16581111, 16769602, 16961627, 17337040, 17803810, 18004210, 18577829, 19576320, 22990067, 23751603, 24262617, 25730082, 27380588, 27566695
PA165374673	ticagrelor	Chemical	Literature, MultilinkAnnotation	associated		24951432
PA165945763	cangrelor	Chemical	ClinicalAnnotation	associated	PD	20126830
PA166129560	major adverse cardiac events (mace)	Disease	ClinicalAnnotation	associated	PD	16405973
PA166156339	rs2046934	Variant	VipGene	associated		14662702, 17337040, 12912815
PA172	GNAI1	Gene	Pathway	associated		20938371
PA173	GNAI3	Gene	Pathway	associated		20938371
PA176	GNB3	Gene	Pathway	associated		20938371
PA24347	GNAI2	Gene	Pathway	associated		20938371
PA443362	Angina Pectoris	Disease	ClinicalAnnotation	associated	PD	12912815, 14662702, 15795539, 16181985, 16405973, 16581111, 16769602, 16961627, 17337040, 17803810, 18004210, 18577829, 19576320, 22990067, 23751603, 24262617, 25730082, 27380588, 27566695
PA443635	Cardiovascular Diseases	Disease	VipGene	associated
PA443672	Ischemic Attack, Transient	Disease	VariantAnnotation	not associated	PD	27450232
PA443783	Constriction, Pathologic	Disease	VariantAnnotation	not associated	PD	27450232
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation	associated	PD	15933261, 18485500, 19106083, 26362473
PA443797	Coronary Disease	Disease	ClinicalAnnotation	associated	PD	27566695
PA447054	Stroke	Disease	VariantAnnotation	not associated	PD	27450232
PA449053	clopidogrel	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PD	12912815, 14662702, 15795539, 15933261, 15955565, 16181985, 16405973, 16581111, 16769602, 16961627, 17337040, 17803810, 18004210, 18485500, 18577829, 19106083, 19576320, 21831410, 22990067, 23751603, 24262617, 24951432, 25730082, 26362473, 27380588, 27450232, 27566695
PA449177	cytarabine	Chemical	MultilinkAnnotation	associated		24444404
PA451686	ticlopidine	Chemical	Pathway, VipGene	associated		15955565, 20938371

References

Pubmed ID	Year	Title	Citations
37525937	2024	Platelet P2Y(12) signalling pathway in the dysregulated immune response during sepsis.	0
38456510	2024	High-mobility group box 1 increases platelet surface P2Y12 and platelet activation in sickle cell disease.	0
37525937	2024	Platelet P2Y(12) signalling pathway in the dysregulated immune response during sepsis.	0
38456510	2024	High-mobility group box 1 increases platelet surface P2Y12 and platelet activation in sickle cell disease.	0
35175489	2023	P2Y12 receptor gene polymorphisms are associated with epilepsy.	3
36681816	2023	Association between P2Y1 and P2Y12 polymorphisms and acute myocardial infarction and ADP-induced platelet aggregation.	0
36743859	2023	Correlation P2Y12 Genetic Polymorphism As Risk Factor of Clopidogrel Resistance in Indonesian Stroke Patients.	1
37589138	2023	Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y(12) and Link to Residual Platelet Reactivity.	0
35175489	2023	P2Y12 receptor gene polymorphisms are associated with epilepsy.	3
36681816	2023	Association between P2Y1 and P2Y12 polymorphisms and acute myocardial infarction and ADP-induced platelet aggregation.	0
36743859	2023	Correlation P2Y12 Genetic Polymorphism As Risk Factor of Clopidogrel Resistance in Indonesian Stroke Patients.	1
37589138	2023	Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y(12) and Link to Residual Platelet Reactivity.	0
34474410	2022	Platelet miR-107 Participates in Clopidogrel Resistance after PCI Treatment by Regulating P2Y12.	2
35266813	2022	Single-nucleotide polymorphisms of the SLC17A9 and P2RY12 genes are significantly associated with phantom tooth pain.	3
36169256	2022	Inhibiting P2Y12 receptor relieves LPS-induced inflammation and endothelial dysfunction.	2

Citation

Dessen P

P2RY12 (purinergic receptor P2Y12)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53601/p2ry12-(purinergic-receptor-p2y12)