Identity
HGNC
LOCATION
3q25.1
LOCUSID
ALIAS
ADPG-R,BDPLT8,HORK3,P2T(AC),P2Y(12)R,P2Y(AC),P2Y(ADP),P2Y(cyc),P2Y12,SP1999
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 64805
MIM: 600515
HGNC: 18124
Ensembl: ENSG00000169313
Variants:
dbSNP: 64805
ClinVar: 64805
TCGA: ENSG00000169313
COSMIC: P2RY12
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000169313 | ENST00000302632 | Q9H244 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA154410481 | prasugrel | Chemical | Literature, MultilinkAnnotation, Pathway | associated | 20938371, 24951432 | ||
| PA165108401 | Acute coronary syndrome | Disease | ClinicalAnnotation | associated | PD | 12912815, 14662702, 15795539, 16181985, 16405973, 16581111, 16769602, 16961627, 17337040, 17803810, 18004210, 18577829, 19576320, 22990067, 23751603, 24262617, 25730082, 27380588, 27566695 | |
| PA165374673 | ticagrelor | Chemical | Literature, MultilinkAnnotation | associated | 24951432 | ||
| PA165945763 | cangrelor | Chemical | ClinicalAnnotation | associated | PD | 20126830 | |
| PA166129560 | major adverse cardiac events (mace) | Disease | ClinicalAnnotation | associated | PD | 16405973 | |
| PA166156339 | rs2046934 | Variant | VipGene | associated | 14662702, 17337040, 12912815 | ||
| PA172 | GNAI1 | Gene | Pathway | associated | 20938371 | ||
| PA173 | GNAI3 | Gene | Pathway | associated | 20938371 | ||
| PA176 | GNB3 | Gene | Pathway | associated | 20938371 | ||
| PA24347 | GNAI2 | Gene | Pathway | associated | 20938371 | ||
| PA443362 | Angina Pectoris | Disease | ClinicalAnnotation | associated | PD | 12912815, 14662702, 15795539, 16181985, 16405973, 16581111, 16769602, 16961627, 17337040, 17803810, 18004210, 18577829, 19576320, 22990067, 23751603, 24262617, 25730082, 27380588, 27566695 | |
| PA443635 | Cardiovascular Diseases | Disease | VipGene | associated | |||
| PA443672 | Ischemic Attack, Transient | Disease | VariantAnnotation | not associated | PD | 27450232 | |
| PA443783 | Constriction, Pathologic | Disease | VariantAnnotation | not associated | PD | 27450232 | |
| PA443796 | Coronary Artery Disease | Disease | ClinicalAnnotation | associated | PD | 15933261, 18485500, 19106083, 26362473 | |
| PA443797 | Coronary Disease | Disease | ClinicalAnnotation | associated | PD | 27566695 | |
| PA447054 | Stroke | Disease | VariantAnnotation | not associated | PD | 27450232 | |
| PA449053 | clopidogrel | Chemical | ClinicalAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene | ambiguous | PD | 12912815, 14662702, 15795539, 15933261, 15955565, 16181985, 16405973, 16581111, 16769602, 16961627, 17337040, 17803810, 18004210, 18485500, 18577829, 19106083, 19576320, 21831410, 22990067, 23751603, 24262617, 24951432, 25730082, 26362473, 27380588, 27450232, 27566695 | |
| PA449177 | cytarabine | Chemical | MultilinkAnnotation | associated | 24444404 | ||
| PA451686 | ticlopidine | Chemical | Pathway, VipGene | associated | 15955565, 20938371 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37525937 | 2024 | Platelet P2Y(12) signalling pathway in the dysregulated immune response during sepsis. | 0 |
| 38456510 | 2024 | High-mobility group box 1 increases platelet surface P2Y12 and platelet activation in sickle cell disease. | 0 |
| 37525937 | 2024 | Platelet P2Y(12) signalling pathway in the dysregulated immune response during sepsis. | 0 |
| 38456510 | 2024 | High-mobility group box 1 increases platelet surface P2Y12 and platelet activation in sickle cell disease. | 0 |
| 35175489 | 2023 | P2Y12 receptor gene polymorphisms are associated with epilepsy. | 3 |
| 36681816 | 2023 | Association between P2Y1 and P2Y12 polymorphisms and acute myocardial infarction and ADP-induced platelet aggregation. | 0 |
| 36743859 | 2023 | Correlation P2Y12 Genetic Polymorphism As Risk Factor of Clopidogrel Resistance in Indonesian Stroke Patients. | 1 |
| 37589138 | 2023 | Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y(12) and Link to Residual Platelet Reactivity. | 0 |
| 35175489 | 2023 | P2Y12 receptor gene polymorphisms are associated with epilepsy. | 3 |
| 36681816 | 2023 | Association between P2Y1 and P2Y12 polymorphisms and acute myocardial infarction and ADP-induced platelet aggregation. | 0 |
| 36743859 | 2023 | Correlation P2Y12 Genetic Polymorphism As Risk Factor of Clopidogrel Resistance in Indonesian Stroke Patients. | 1 |
| 37589138 | 2023 | Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y(12) and Link to Residual Platelet Reactivity. | 0 |
| 34474410 | 2022 | Platelet miR-107 Participates in Clopidogrel Resistance after PCI Treatment by Regulating P2Y12. | 2 |
| 35266813 | 2022 | Single-nucleotide polymorphisms of the SLC17A9 and P2RY12 genes are significantly associated with phantom tooth pain. | 3 |
| 36169256 | 2022 | Inhibiting P2Y12 receptor relieves LPS-induced inflammation and endothelial dysfunction. | 2 |
Citation
Dessen P
P2RY12 (purinergic receptor P2Y12)
Atlas Genet Cytogenet Oncol Haematol. 2013-11-01
Online version: http://atlasgeneticsoncology.org/gene/53601/p2ry12-(purinergic-receptor-p2y12)
