RCC2 (regulator of chromosome condensation 2)

2013-11-01   Dessen P  

Identity

HGNC
RCC2
LOCATION
1p36.13
LOCUSID
55920
ALIAS
TD-60
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55920
MIM: 609587
HGNC: 30297
Ensembl: ENSG00000179051

Variants:

dbSNP: 55920
ClinVar: 55920
TCGA: ENSG00000179051
COSMIC: RCC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179051ENST00000375433Q9P258
ENSG00000179051ENST00000375433A0A024RAC5
ENSG00000179051ENST00000375436Q9P258
ENSG00000179051ENST00000375436A0A024RAC5

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365933852023LncRNA HOTAIR enhances RCC2 to accelerate cervical cancer progression by sponging miR-331-3p.1
380087512023RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells.2
365933852023LncRNA HOTAIR enhances RCC2 to accelerate cervical cancer progression by sponging miR-331-3p.1
380087512023RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells.2
361167402022The mitotic regulator RCC2 promotes glucose metabolism through BACH1-dependent transcriptional upregulation of hexokinase II in glioma.5
361167402022The mitotic regulator RCC2 promotes glucose metabolism through BACH1-dependent transcriptional upregulation of hexokinase II in glioma.5
312779422019RCC2 promotes proliferation and radio-resistance in glioblastoma via activating transcription of DNMT1.15
312779422019RCC2 promotes proliferation and radio-resistance in glioblastoma via activating transcription of DNMT1.15
288695982018RCC2 is a novel p53 target in suppressing metastasis.11
293210042018RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation.25
299134392018LncRNA LCPAT1 Mediates Smoking/ Particulate Matter 2.5-Induced Cell Autophagy and Epithelial-Mesenchymal Transition in Lung Cancer Cells via RCC2.28
288695982018RCC2 is a novel p53 target in suppressing metastasis.11
293210042018RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation.25
299134392018LncRNA LCPAT1 Mediates Smoking/ Particulate Matter 2.5-Induced Cell Autophagy and Epithelial-Mesenchymal Transition in Lung Cancer Cells via RCC2.28
286069212017Overexpression of RCC2 Enhances Cell Motility and Promotes Tumor Metastasis in Lung Adenocarcinoma by Inducing Epithelial-Mesenchymal Transition.36

Citation

Dessen P

RCC2 (regulator of chromosome condensation 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53610/rcc2-(regulator-of-chromosome-condensation-2)