ZNF423 (zinc finger protein 423)

2013-11-01 Affiliation

Identity

HGNC

ZNF423

LOCATION

16q12.1

LOCUSID

23090

ALIAS

Ebfaz,JBTS19,NPHP14,OAZ,Roaz,ZFP423,Zfp104,hOAZ

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23090
MIM: 604557
HGNC: 16762
Ensembl: ENSG00000102935

Variants:

dbSNP: 23090
ClinVar: 23090
TCGA: ENSG00000102935
COSMIC: ZNF423

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000102935	ENST00000262383	Q2M1K9
ENSG00000102935	ENST00000535559	F5H7S1
ENSG00000102935	ENST00000561648	Q2M1K9
ENSG00000102935	ENST00000562520	Q2M1K9
ENSG00000102935	ENST00000562871	Q2M1K9
ENSG00000102935	ENST00000563137	Q2M1K9
ENSG00000102935	ENST00000567169	F5H7S1
ENSG00000102935	ENST00000568094	A0A087WV99

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation	associated	PD	23764426
PA451221	raloxifene	Chemical	ClinicalAnnotation	associated	PD	23764426
PA451581	tamoxifen	Chemical	ClinicalAnnotation	associated	PD	23764426

References

Pubmed ID	Year	Title	Citations
35313831	2022	Expression of the preadipocyte marker ZFP423 is dysregulated between well-differentiated and dedifferentiated liposarcoma.	2
35313831	2022	Expression of the preadipocyte marker ZFP423 is dysregulated between well-differentiated and dedifferentiated liposarcoma.	2
32925911	2020	ZNF423 patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities.	5
32925911	2020	ZNF423 patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities.	5
31283791	2019	Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease.	16
31284679	2019	Roles of Zinc Finger Protein 423 in Proliferation and Invasion of Cholangiocarcinoma through Oxidative Stress.	7
31283791	2019	Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease.	16
31284679	2019	Roles of Zinc Finger Protein 423 in Proliferation and Invasion of Cholangiocarcinoma through Oxidative Stress.	7
28821270	2017	Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion.	13
28968398	2017	SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ERα-positive breast cancer through regulation of BRCA1.	15
28821270	2017	Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion.	13
28968398	2017	SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ERα-positive breast cancer through regulation of BRCA1.	15
26788497	2015	ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies.	19
26788497	2015	ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies.	19
25219468	2014	Restored immunosuppressive effect of mesenchymal stem cells on B cells after olfactory 1/early B cell factor-associated zinc-finger protein down-regulation in patients with systemic lupus erythematosus.	22

Citation

Dessen P

ZNF423 (zinc finger protein 423)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53614/znf423-(zinc-finger-protein-423)