Identity
HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
C5A,C5AR,C5R1,CD88
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 728
MIM: 113995
HGNC: 1338
Ensembl: ENSG00000197405
Variants:
dbSNP: 728
ClinVar: 728
TCGA: ENSG00000197405
COSMIC: C5AR1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000197405 | ENST00000355085 | P21730 |
| ENSG00000197405 | ENST00000594787 | M0QZK7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37890688 | 2024 | The C5aR1 complement receptor: A novel immunomodulator of insulin action in skeletal muscle. | 0 |
| 37909169 | 2024 | Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage. | 1 |
| 38071913 | 2024 | C5a enhances inflammation and chemotaxis of γδ T cells in malignant pleural effusion. | 0 |
| 38098230 | 2024 | Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity. | 2 |
| 38101498 | 2024 | Differential contributions of the C5b-9 and C5a/C5aR pathways to microvascular and macrovascular thrombosis in complement-mediated thrombotic microangiopathy patients. | 0 |
| 38252818 | 2024 | Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing. | 0 |
| 38458648 | 2024 | C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis. | 0 |
| 37890688 | 2024 | The C5aR1 complement receptor: A novel immunomodulator of insulin action in skeletal muscle. | 0 |
| 37909169 | 2024 | Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage. | 1 |
| 38071913 | 2024 | C5a enhances inflammation and chemotaxis of γδ T cells in malignant pleural effusion. | 0 |
| 38098230 | 2024 | Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity. | 2 |
| 38101498 | 2024 | Differential contributions of the C5b-9 and C5a/C5aR pathways to microvascular and macrovascular thrombosis in complement-mediated thrombotic microangiopathy patients. | 0 |
| 38252818 | 2024 | Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing. | 0 |
| 38458648 | 2024 | C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis. | 0 |
| 36107247 | 2023 | C5α secreted by tumor mesenchymal stem-like cells mediates resistance to 5-aminolevulinic acid-based photodynamic therapy against glioblastoma tumorspheres. | 1 |
Citation
Dessen P
C5AR1 (complement C5a receptor 1)
Atlas Genet Cytogenet Oncol Haematol. 2013-11-01
Online version: http://atlasgeneticsoncology.org/gene/53617/c5ar1-(complement-c5a-receptor-1)
