EIF4E3 (eukaryotic translation initiation factor 4E family member 3)

2013-11-01  

Identity

HGNC
EIF4E3
LOCATION
3p13
LOCUSID
317649
ALIAS
eIF-4E3,eIF4E-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 317649
MIM: 609896
HGNC: 31837
Ensembl: ENSG00000163412

Variants:

dbSNP: 317649
ClinVar: 317649
TCGA: ENSG00000163412
COSMIC: EIF4E3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163412ENST00000295612Q8N5X7
ENSG00000163412ENST00000389826Q8N5X7
ENSG00000163412ENST00000421769Q8N5X7
ENSG00000163412ENST00000425534Q8N5X7
ENSG00000163412ENST00000448225Q8N5X7
ENSG00000163412ENST00000469524C9JUY2
ENSG00000163412ENST00000496214C9J6E5
ENSG00000163412ENST00000497838C9J7Z6

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370674012023m7G-related genes-NCBP2 and EIF4E3 determine immune contexture in head and neck squamous cell carcinoma by regulating CCL4/CCL5 expression.7
370674012023m7G-related genes-NCBP2 and EIF4E3 determine immune contexture in head and neck squamous cell carcinoma by regulating CCL4/CCL5 expression.7
338938022021eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome.12
338938022021eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome.12
289425922018Major splice variants and multiple polyadenylation site utilization in mRNAs encoding human translation initiation factors eIF4E1 and eIF4E3 regulate the translational regulators?4
289425922018Major splice variants and multiple polyadenylation site utilization in mRNAs encoding human translation initiation factors eIF4E1 and eIF4E3 regulate the translational regulators?4
275781492016Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules.22
275781492016Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules.22
254032302014MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.47
254032302014MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.47
235879182013eIF4E3, a new actor in mRNA metabolism and tumor suppression.21
235879182013eIF4E3, a new actor in mRNA metabolism and tumor suppression.21

Citation

Dessen P

EIF4E3 (eukaryotic translation initiation factor 4E family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53621/eif4e3-(eukaryotic-translation-initiation-factor-4e-family-member-3)