Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 316
MIM: 602841
HGNC: 553
Ensembl: ENSG00000138356
Variants:
dbSNP: 316
ClinVar: 316
TCGA: ENSG00000138356
COSMIC: AOX1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000138356 | ENST00000260930 | H7BXF7 |
| ENSG00000138356 | ENST00000374700 | Q06278 |
| ENSG00000138356 | ENST00000439380 | H7C3Q1 |
| ENSG00000138356 | ENST00000454629 | C9J244 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165958521 | febuxostat | Chemical | ClinicalAnnotation | associated | PD | 27798726 | |
| PA166114484 | XK469 | Chemical | ClinicalAnnotation | associated | PK | ||
| PA444318 | Gout | Disease | ClinicalAnnotation | associated | PD | 27798726 | |
| PA446116 | Inflammatory Bowel Diseases | Disease | ClinicalAnnotation | associated | PD | 19500084 | |
| PA448320 | allopurinol | Chemical | ClinicalAnnotation | associated | PD | 27798726 | |
| PA448515 | azathioprine | Chemical | ClinicalAnnotation | associated | PD | 19500084 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38199597 | 2024 | Aldehyde oxidase 1 promotes gallbladder carcinogenesis through ROS-mediated activation of the Wnt/β-catenin pathway. | 0 |
| 39034354 | 2024 | Role of AOX1 on RXR signaling regulates osteoblastogenesis in hPDLMSCs. | 0 |
| 38199597 | 2024 | Aldehyde oxidase 1 promotes gallbladder carcinogenesis through ROS-mediated activation of the Wnt/β-catenin pathway. | 0 |
| 39034354 | 2024 | Role of AOX1 on RXR signaling regulates osteoblastogenesis in hPDLMSCs. | 0 |
| 35354150 | 2023 | DNA Methylation-Mediated Lowly Expressed AOX1 Promotes Cell Migration and Invasion of Prostate Cancer. | 3 |
| 37827455 | 2023 | Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues. | 0 |
| 35354150 | 2023 | DNA Methylation-Mediated Lowly Expressed AOX1 Promotes Cell Migration and Invasion of Prostate Cancer. | 3 |
| 37827455 | 2023 | Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues. | 0 |
| 31383940 | 2020 | Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. | 30 |
| 31993760 | 2020 | Population Pharmacokinetics of Sulindac and Genetic Polymorphisms of FMO3 and AOX1 in Women with Preterm Labor. | 3 |
| 32470878 | 2020 | Aldehyde oxidase 1 promoted the occurrence and development of colorectal cancer by up-regulation of expression of CD133. | 9 |
| 31383940 | 2020 | Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. | 30 |
| 31993760 | 2020 | Population Pharmacokinetics of Sulindac and Genetic Polymorphisms of FMO3 and AOX1 in Women with Preterm Labor. | 3 |
| 32470878 | 2020 | Aldehyde oxidase 1 promoted the occurrence and development of colorectal cancer by up-regulation of expression of CD133. | 9 |
| 30985987 | 2019 | Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms. | 0 |
Citation
Dessen P
AOX1 (aldehyde oxidase 1)
Atlas Genet Cytogenet Oncol Haematol. 2013-11-01
Online version: http://atlasgeneticsoncology.org/gene/53623/aox1-(aldehyde-oxidase-1)
