Identity
HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
DGCR1,TUP1,TUPLE1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7290
MIM: 600237
HGNC: 4916
Ensembl: ENSG00000100084
Variants:
dbSNP: 7290
ClinVar: 7290
TCGA: ENSG00000100084
COSMIC: HIRA
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000100084 | ENST00000263208 | P54198 |
| ENSG00000100084 | ENST00000340170 | P54198 |
| ENSG00000100084 | ENST00000452818 | H7C2A7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38824221 | 2024 | Disparity of gene expression in coronary artery disease: insights from MEIS1, HIRA, and Myocardin. | 0 |
| 38824221 | 2024 | Disparity of gene expression in coronary artery disease: insights from MEIS1, HIRA, and Myocardin. | 0 |
| 37227756 | 2023 | Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus. | 5 |
| 37638746 | 2023 | HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers. | 0 |
| 37227756 | 2023 | Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus. | 5 |
| 37638746 | 2023 | HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers. | 0 |
| 34626773 | 2022 | DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC. | 4 |
| 35643233 | 2022 | HIRA Supports Hepatitis B Virus Minichromosome Establishment and Transcriptional Activity in Infected Hepatocytes. | 8 |
| 34626773 | 2022 | DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC. | 4 |
| 35643233 | 2022 | HIRA Supports Hepatitis B Virus Minichromosome Establishment and Transcriptional Activity in Infected Hepatocytes. | 8 |
| 33417013 | 2021 | Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth. | 7 |
| 33835048 | 2021 | HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype. | 3 |
| 34074949 | 2021 | Haploinsufficiency of the HIRA gene may not always produce severe neurodevelopmental consequences. | 0 |
| 34158510 | 2021 | Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA. | 9 |
| 33417013 | 2021 | Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth. | 7 |
Citation
Dessen P
HIRA (histone cell cycle regulator)
Atlas Genet Cytogenet Oncol Haematol. 2013-12-01
Online version: http://atlasgeneticsoncology.org/gene/53629/hira-(histone-cell-cycle-regulator)
