HIRA (histone cell cycle regulator)

2013-12-01  

Identity

HGNC
HIRA
LOCATION
22q11.21
LOCUSID
7290
ALIAS
DGCR1,TUP1,TUPLE1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7290
MIM: 600237
HGNC: 4916
Ensembl: ENSG00000100084

Variants:

dbSNP: 7290
ClinVar: 7290
TCGA: ENSG00000100084
COSMIC: HIRA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100084ENST00000263208P54198
ENSG00000100084ENST00000340170P54198
ENSG00000100084ENST00000452818H7C2A7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
388242212024Disparity of gene expression in coronary artery disease: insights from MEIS1, HIRA, and Myocardin.0
388242212024Disparity of gene expression in coronary artery disease: insights from MEIS1, HIRA, and Myocardin.0
372277562023Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus.5
376387462023HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers.0
372277562023Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus.5
376387462023HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers.0
346267732022DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC.4
356432332022HIRA Supports Hepatitis B Virus Minichromosome Establishment and Transcriptional Activity in Infected Hepatocytes.8
346267732022DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC.4
356432332022HIRA Supports Hepatitis B Virus Minichromosome Establishment and Transcriptional Activity in Infected Hepatocytes.8
334170132021Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth.7
338350482021HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype.3
340749492021Haploinsufficiency of the HIRA gene may not always produce severe neurodevelopmental consequences.0
341585102021Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA.9
334170132021Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth.7

Citation

Dessen P

HIRA (histone cell cycle regulator)

Atlas Genet Cytogenet Oncol Haematol. 2013-12-01

Online version: http://atlasgeneticsoncology.org/gene/53629/hira-(histone-cell-cycle-regulator)