Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 486
MIM: 601814
HGNC: 4026
Ensembl: ENSG00000137731
Variants:
dbSNP: 486
ClinVar: 486
TCGA: ENSG00000137731
COSMIC: FXYD2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000137731 | ENST00000260287 | P54710 |
| ENSG00000137731 | ENST00000292079 | P54710 |
| ENSG00000137731 | ENST00000528014 | P54710 |
| ENSG00000137731 | ENST00000532119 | P54710 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA24994 | ARNT | Gene | Pathway | associated | 23788015 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36313180 | 2022 | Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma. | 0 |
| 36313180 | 2022 | Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma. | 0 |
| 26910837 | 2016 | Targeting FXYD2 by cardiac glycosides potently blocks tumor growth in ovarian clear cell carcinoma. | 15 |
| 26910837 | 2016 | Targeting FXYD2 by cardiac glycosides potently blocks tumor growth in ovarian clear cell carcinoma. | 15 |
| 24794573 | 2015 | Structure of the Na,K-ATPase regulatory protein FXYD2b in micelles: implications for membrane-water interfacial arginines. | 6 |
| 25765846 | 2015 | Recurrent FXYD2 p.Gly41Arg mutation in patients with isolated dominant hypomagnesaemia. | 24 |
| 24794573 | 2015 | Structure of the Na,K-ATPase regulatory protein FXYD2b in micelles: implications for membrane-water interfacial arginines. | 6 |
| 25765846 | 2015 | Recurrent FXYD2 p.Gly41Arg mutation in patients with isolated dominant hypomagnesaemia. | 24 |
| 24204001 | 2014 | Mutations in PCBD1 cause hypomagnesemia and renal magnesium wasting. | 30 |
| 24258619 | 2014 | FXYD2c plays a potential role in modulating Na(+)/K (+)-ATPase activity in HK-2 cells upon hypertonic challenge. | 2 |
| 24204001 | 2014 | Mutations in PCBD1 cause hypomagnesemia and renal magnesium wasting. | 30 |
| 24258619 | 2014 | FXYD2c plays a potential role in modulating Na(+)/K (+)-ATPase activity in HK-2 cells upon hypertonic challenge. | 2 |
| 23196795 | 2013 | Expression of the Na+/K+-transporting ATPase gamma subunit FXYD2 in renal tumors. | 8 |
| 23196795 | 2013 | Expression of the Na+/K+-transporting ATPase gamma subunit FXYD2 in renal tumors. | 8 |
| 22588134 | 2012 | Identification of a crab gill FXYD2 protein and regulation of crab microsomal Na,K-ATPase activity by mammalian FXYD2 peptide. | 3 |
Citation
Dessen P
FXYD2 (FXYD domain containing ion transport regulator 2)
Atlas Genet Cytogenet Oncol Haematol. 2013-12-01
Online version: http://atlasgeneticsoncology.org/gene/53632/fxyd2-(fxyd-domain-containing-ion-transport-regulator-2)
