CISD2 (CDGSH iron sulfur domain 2)

2013-12-01  

Identity

HGNC
LOCATION
4q24
LOCUSID
ALIAS
ERIS,Miner1,NAF-1,WFS2,ZCD2
FUSION GENES

Other Information

Locus ID:

NCBI: 493856
MIM: 611507
HGNC: 24212
Ensembl: ENSG00000145354

Variants:

dbSNP: 493856
ClinVar: 493856
TCGA: ENSG00000145354
COSMIC: CISD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145354ENST00000273986Q8N5K1
ENSG00000145354ENST00000503643D6RCF4
ENSG00000145354ENST00000574446I3L1N9
ENSG00000145354ENST00000643561A0A2R8Y4Y3
ENSG00000145354ENST00000646632A0A2R8Y540

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200106952010Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1.89
239598812013NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth.53
247068572014Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.26
289835962017CISD2 promotes the proliferation of glioma cells via suppressing beclin‑1‑mediated autophagy and is targeted by microRNA‑449a.7
147247302003Wolfram syndrome: phenotype and novel mutation in two Taiwanese siblings.0
178469942007A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2.0
195808162009Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2.0
206495402010A role for the CISD2 gene in lifespan control and human disease.0
237173862013Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs.0
251349192014CISD2 expression is a novel marker correlating with pelvic lymph node metastasis and prognosis in patients with early-stage cervical cancer.0

Citation

Dessen P

CISD2 (CDGSH iron sulfur domain 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-12-01

Online version: http://atlasgeneticsoncology.org/gene/53644/cisd2-(cdgsh-iron-sulfur-domain-2)