CISD2 (CDGSH iron sulfur domain 2)

2013-12-01  

Identity

HGNC
CISD2
LOCATION
4q24
LOCUSID
493856
ALIAS
ERIS,Miner1,NAF-1,WFS2,ZCD2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 493856
MIM: 611507
HGNC: 24212
Ensembl: ENSG00000145354

Variants:

dbSNP: 493856
ClinVar: 493856
TCGA: ENSG00000145354
COSMIC: CISD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145354ENST00000273986Q8N5K1
ENSG00000145354ENST00000503643D6RCF4
ENSG00000145354ENST00000574446I3L1N9
ENSG00000145354ENST00000643561A0A2R8Y4Y3
ENSG00000145354ENST00000646632A0A2R8Y540

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386788192024A preliminary study unveils CISD2 as a ferroptosis-related therapeutic target for recurrent spontaneous abortion through immunological analysis and two-sample mendelian randomization.0
388142132024Overexpression of CISD2 alleviates septic acute kidney injury via activating Sonic Hedgehog signaling pathway.0
386788192024A preliminary study unveils CISD2 as a ferroptosis-related therapeutic target for recurrent spontaneous abortion through immunological analysis and two-sample mendelian randomization.0
388142132024Overexpression of CISD2 alleviates septic acute kidney injury via activating Sonic Hedgehog signaling pathway.0
372497592023CISD2 promotes lung squamous carcinoma cell migration and invasion via the TGF-β1-induced Smad2/3 signaling pathway.2
372497592023CISD2 promotes lung squamous carcinoma cell migration and invasion via the TGF-β1-induced Smad2/3 signaling pathway.2
358197092022CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen-glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway.1
358197092022CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen-glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway.1
334226172021CISD2 maintains cellular homeostasis.28
334778092021The NFκB Antagonist CDGSH Iron-Sulfur Domain 2 Is a Promising Target for the Treatment of Neurodegenerative Diseases.7
337520602021CISD2 plays a role in age-related diseases and cancer.6
345473712021Disrupting CISD2 function in cancer cells primarily impacts mitochondrial labile iron levels and triggers TXNIP expression.18
347401042021Cisd2 plays an essential role in corneal epithelial regeneration.9
334226172021CISD2 maintains cellular homeostasis.28
334778092021The NFκB Antagonist CDGSH Iron-Sulfur Domain 2 Is a Promising Target for the Treatment of Neurodegenerative Diseases.7

Citation

Dessen P

CISD2 (CDGSH iron sulfur domain 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-12-01

Online version: http://atlasgeneticsoncology.org/gene/53644/cisd2-(cdgsh-iron-sulfur-domain-2)