MLST8 (MTOR associated protein, LST8 homolog)

2013-12-01 Affiliation

Identity

HGNC

MLST8

LOCATION

16p13.3

LOCUSID

64223

ALIAS

GBL,GbetaL,LST8,POP3,WAT1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 64223
MIM: 612190
HGNC: 24825
Ensembl: ENSG00000167965

Variants:

dbSNP: 64223
ClinVar: 64223
TCGA: ENSG00000167965
COSMIC: MLST8

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000167965	ENST00000301724	A0A0A0MR05
ENSG00000167965	ENST00000382450	Q9BVC4
ENSG00000167965	ENST00000397124	Q9BVC4
ENSG00000167965	ENST00000562352	H3BSZ4
ENSG00000167965	ENST00000562479	H3BR25
ENSG00000167965	ENST00000562851	H3BR38
ENSG00000167965	ENST00000563107	H3BPU5
ENSG00000167965	ENST00000563179	H3BQ74
ENSG00000167965	ENST00000564088	Q9BVC4
ENSG00000167965	ENST00000565250	Q9BVC4
ENSG00000167965	ENST00000565687	H3BM50
ENSG00000167965	ENST00000565717	H3BR38
ENSG00000167965	ENST00000566835	H3BPT1
ENSG00000167965	ENST00000567282	I3L2E7
ENSG00000167965	ENST00000567623	H3BM50
ENSG00000167965	ENST00000569417	Q9BVC4
ENSG00000167965	ENST00000569457	H3BN58
ENSG00000167965	ENST00000570224	H3BR38

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Autophagy - animal	KEGG	ko04140
mTOR signaling pathway	KEGG	ko04150
Autophagy - animal	KEGG	hsa04140
mTOR signaling pathway	KEGG	hsa04150
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
PI3K/AKT Signaling in Cancer	REACTOME	R-HSA-2219528
Constitutive Signaling by AKT1 E17K in Cancer	REACTOME	R-HSA-5674400
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Costimulation by the CD28 family	REACTOME	R-HSA-388841
CD28 co-stimulation	REACTOME	R-HSA-389356
CD28 dependent PI3K/Akt signaling	REACTOME	R-HSA-389357
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GAB1 signalosome	REACTOME	R-HSA-180292
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
PI3K Cascade	REACTOME	R-HSA-109704
PKB-mediated events	REACTOME	R-HSA-109703
mTOR signalling	REACTOME	R-HSA-165159
mTORC1-mediated signalling	REACTOME	R-HSA-166208
Energy dependent regulation of mTOR by LKB1-AMPK	REACTOME	R-HSA-380972
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated vascular permeability	REACTOME	R-HSA-5218920
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Metabolic Genes	REACTOME	R-HSA-5628897
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
HSF1-dependent transactivation	REACTOME	R-HSA-3371571
Macroautophagy	REACTOME	R-HSA-1632852
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Expression and Degradation	REACTOME	R-HSA-6806003
Regulation of TP53 Degradation	REACTOME	R-HSA-6804757
Autophagy - other	KEGG	ko04136
Autophagy - other	KEGG	hsa04136

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
23423739	2013	Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population.	75
21454807	2011	Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4.	31
24337580	2014	Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.	28
21321085	2011	Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57.	20
21283628	2011	E2F1 regulates cellular growth by mTORC1 signaling.	17
28475179	2017	mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism.	17
28643459	2017	Construction of competitive endogenous RNA network reveals regulatory role of long non-coding RNAs in type 2 diabetes mellitus.	16
25906254	2015	mLST8 Promotes mTOR-Mediated Tumor Progression.	10
22258093	2012	Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro.	9
26787466	2016	The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity.	7

Citation

Dessen P

MLST8 (MTOR associated protein, LST8 homolog)

Atlas Genet Cytogenet Oncol Haematol. 2013-12-01

Online version: http://atlasgeneticsoncology.org/gene/53645/mlst8-(mtor-associated-protein-lst8-homolog)