AJUBA (ajuba LIM protein)

2014-01-01 Affiliation

Identity

HGNC

AJUBA

LOCATION

14q11.2

LOCUSID

84962

ALIAS

JUB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84962
MIM: 609066
HGNC: 20250
Ensembl: ENSG00000129474

Variants:

dbSNP: 84962
ClinVar: 84962
TCGA: ENSG00000129474
COSMIC: AJUBA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000129474	ENST00000262713	Q96IF1
ENSG00000129474	ENST00000361265	Q96IF1
ENSG00000129474	ENST00000397388	Q96IF1
ENSG00000129474	ENST00000553592	G3V481
ENSG00000129474	ENST00000553736	H0YJL9
ENSG00000129474	ENST00000553911	G3V5F5
ENSG00000129474	ENST00000556731	G3V481

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
Regulation of PLK1 Activity at G2/M Transition	REACTOME	R-HSA-2565942
Developmental Biology	REACTOME	R-HSA-1266738
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to hypoxia	REACTOME	R-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygen	REACTOME	R-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	REACTOME	R-HSA-1234176
Activation of HOX genes during differentiation	REACTOME	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	REACTOME	R-HSA-5617472
Hippo signaling pathway -multiple species	KEGG	ko04392
Hippo signaling pathway -multiple species	KEGG	hsa04392

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12417594	2003	The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin.	55
15870274	2005	The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex.	33
22105346	2011	Ajuba is required for Rac activation and maintenance of E-cadherin adhesion.	32
18805794	2008	Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor.	30
17621269	2008	Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin.	23
24336325	2015	LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade.	23
15870270	2005	The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha.	22
20133701	2010	LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling.	20
29440237	2018	Tension-dependent regulation of mammalian Hippo signaling through LIMD1.	17
20508983	2011	Centrosome-related genes, genetic variation, and risk of breast cancer.	16

Citation

Dessen P

AJUBA (ajuba LIM protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53655/ajuba-(ajuba-lim-protein)