MGA (MAX dimerization protein MGA)

2014-01-01 Affiliation

Identity

HGNC

MGA

LOCATION

15q15.1

LOCUSID

23269

ALIAS

MAD5,MXD5

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23269
MIM: 616061
HGNC: 14010
Ensembl: ENSG00000174197

Variants:

dbSNP: 23269
ClinVar: 23269
TCGA: ENSG00000174197
COSMIC: MGA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000174197	ENST00000219905	Q8IWI9
ENSG00000174197	ENST00000545763	Q8IWI9
ENSG00000174197	ENST00000561532	H3BTN2
ENSG00000174197	ENST00000563576	H3BTF4
ENSG00000174197	ENST00000564190	H3BU53
ENSG00000174197	ENST00000566586	Q8IWI9
ENSG00000174197	ENST00000566718	H3BP52
ENSG00000174197	ENST00000570161	Q8IWI9
ENSG00000174197	ENST00000619521	A0A087X194

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38454121	2024	Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia.	1
38454121	2024	Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia.	1
31862696	2020	Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma.	19
31862696	2020	Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma.	19
29525183	2018	LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways.	50
29525183	2018	LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways.	50
27306572	2016	Somatic mutation of a candidate tumour suppressor MGA gene and its mutational heterogeneity in colorectal cancers.	9
27306572	2016	Somatic mutation of a candidate tumour suppressor MGA gene and its mutational heterogeneity in colorectal cancers.	9
26272389	2015	Generation of monoclonal antibodies against MGA and comparison of their application in breast cancer detection by immunohistochemistry.	3
26272389	2015	Generation of monoclonal antibodies against MGA and comparison of their application in breast cancer detection by immunohistochemistry.	3
24131248	2014	TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection.	34
24362264	2014	MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1.	87
24131248	2014	TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection.	34
24362264	2014	MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1.	87

Citation

Dessen P

MGA (MAX dimerization protein MGA)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53659