Identity
HGNC
LOCATION
1p32.2
LOCUSID
ALIAS
2010001O09Rik,DAB1,MPRP-1,MPRP1,YKR087C,ZMPOMA1,peptidase
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 115209
MIM: 617081
HGNC: 29661
Ensembl: ENSG00000162600
Variants:
dbSNP: 115209
ClinVar: 115209
TCGA: ENSG00000162600
COSMIC: OMA1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Programmed Cell Death | REACTOME | R-HSA-5357801 |
| Apoptosis | REACTOME | R-HSA-109581 |
| Regulation of Apoptosis | REACTOME | R-HSA-169911 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38530280 | 2024 | OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization. | 1 |
| 38604814 | 2024 | OMA1 competitively binds to HSPA9 to promote mitophagy and activate the cGAS-STING pathway to mediate GBM immune escape. | 0 |
| 39039850 | 2024 | Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD. | 0 |
| 38530280 | 2024 | OMA1 protease eliminates arrested protein import intermediates upon mitochondrial depolarization. | 1 |
| 38604814 | 2024 | OMA1 competitively binds to HSPA9 to promote mitophagy and activate the cGAS-STING pathway to mediate GBM immune escape. | 0 |
| 39039850 | 2024 | Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD. | 0 |
| 36782343 | 2023 | Long Noncoding RNA PCGEM1 Facilitates Tumor Growth and Metastasis of Osteosarcoma by Sponging miR-433-3p and Targeting OMA1. | 1 |
| 37002921 | 2023 | The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage. | 1 |
| 36782343 | 2023 | Long Noncoding RNA PCGEM1 Facilitates Tumor Growth and Metastasis of Osteosarcoma by Sponging miR-433-3p and Targeting OMA1. | 1 |
| 37002921 | 2023 | The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage. | 1 |
| 35163244 | 2022 | The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer. | 12 |
| 35163244 | 2022 | The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer. | 12 |
| 33130089 | 2021 | OMA1-An integral membrane protease? | 11 |
| 34400172 | 2021 | Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease. | 2 |
| 34414449 | 2021 | Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR‑1276/SIRT4 axis. | 5 |
Citation
Dessen P
OMA1 (OMA1 zinc metallopeptidase)
Atlas Genet Cytogenet Oncol Haematol. 2014-01-01
Online version: http://atlasgeneticsoncology.org/gene/53667/oma1-(oma1-zinc-metallopeptidase)
