CLEC4M (C-type lectin domain family 4 member M)

2014-01-01 Affiliation

Identity

HGNC

CLEC4M

LOCATION

19p13.2

LOCUSID

10332

ALIAS

CD209L,CD299,DC-SIGN2,DC-SIGNR,DCSIGNR,HP10347,L-SIGN,LSIGN

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10332
MIM: 605872
HGNC: 13523
Ensembl: ENSG00000104938

Variants:

dbSNP: 10332
ClinVar: 10332
TCGA: ENSG00000104938
COSMIC: CLEC4M

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104938	ENST00000248228	Q9H2X3
ENSG00000104938	ENST00000327325	Q9H2X3
ENSG00000104938	ENST00000334806	H7BXU4
ENSG00000104938	ENST00000359059	Q9H2X3
ENSG00000104938	ENST00000394122	E7ENS9
ENSG00000104938	ENST00000595496	Q9H2X3
ENSG00000104938	ENST00000595751	M0QZ42
ENSG00000104938	ENST00000596363	Q9H2X3
ENSG00000104938	ENST00000596707	M0QYX2
ENSG00000104938	ENST00000597522	Q9H2X3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12050398	2002	C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.	258
15496474	2004	CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus.	227
11739956	2001	Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.	217
15371595	2004	L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus.	75
16434485	2006	DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production.	75
16369534	2006	Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection.	72
15509576	2005	Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR.	66
17006978	2006	Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo.	54
21191006	2011	N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN.	50
17715238	2007	Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entry.	47

Citation

Dessen P

CLEC4M (C-type lectin domain family 4 member M)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53673/clec4m-(c-type-lectin-domain-family-4-member-m)