MUC20 (mucin 20, cell surface associated)

2014-01-01  

Identity

HGNC
LOCATION
3q29
LOCUSID
ALIAS
MUC-20

Other Information

Locus ID:

NCBI: 200958
MIM: 610360
HGNC: 23282
Ensembl: ENSG00000176945

Variants:

dbSNP: 200958
ClinVar: 200958
TCGA: ENSG00000176945
COSMIC: MUC20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176945ENST00000320736E9PH32
ENSG00000176945ENST00000423938H7C102
ENSG00000176945ENST00000436408C9JJE7
ENSG00000176945ENST00000445522Q8N307
ENSG00000176945ENST00000447234Q8N307

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Termination of O-glycan biosynthesisREACTOMER-HSA-977068
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480
Signal TransductionREACTOMER-HSA-162582
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)REACTOMER-HSA-5083632
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)REACTOMER-HSA-5083625
Defective GALNT12 causes colorectal cancer 1 (CRCS1)REACTOMER-HSA-5083636
Signaling by METREACTOMER-HSA-6806834
MET activates RAS signalingREACTOMER-HSA-8851805

References

Pubmed IDYearTitleCitations
350657082022A flexible summary statistics-based colocalization method with application to the mucin cystic fibrosis lung disease modifier locus.5
351669582022Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer.12
350657082022A flexible summary statistics-based colocalization method with application to the mucin cystic fibrosis lung disease modifier locus.5
351669582022Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer.12
336205752021Identification of oral squamous cell carcinoma markers MUC2 and SPRR1B downstream of TANGO.0
346514282021Mucin 20 modulates proteasome capacity through c-Met signalling to increase carfilzomib sensitivity in mantle cell lymphoma.2
336205752021Identification of oral squamous cell carcinoma markers MUC2 and SPRR1B downstream of TANGO.0
346514282021Mucin 20 modulates proteasome capacity through c-Met signalling to increase carfilzomib sensitivity in mantle cell lymphoma.2
318983642020Lnc-MUC20-9 binds to ROCK1 and functions as a tumor suppressor in bladder cancer.6
318983642020Lnc-MUC20-9 binds to ROCK1 and functions as a tumor suppressor in bladder cancer.6
315194212019MUC20 expression marks the receptive phase of the human endometrium.2
315194212019MUC20 expression marks the receptive phase of the human endometrium.2
299930372018Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway.23
302361272018Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas.35
299930372018Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway.23

Citation

Dessen P

MUC20 (mucin 20, cell surface associated)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53678/muc20-(mucin-20-cell-surface-associated)