Identity
HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
DCAF3,WDR94
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55626
MIM: 611359
HGNC: 25990
Ensembl: ENSG00000110497
Variants:
dbSNP: 55626
ClinVar: 55626
TCGA: ENSG00000110497
COSMIC: AMBRA1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37806389 | 2024 | Ambra1 in exosomes secreted by HK-2 cells damaged by supersaturated oxalate induce mitophagy and autophagy-ferroptosis in normal HK-2 cells to participate in the occurrence of kidney stones. | 4 |
| 38424148 | 2024 | AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner. | 0 |
| 38497391 | 2024 | sh- Ambra1 inhibits IRS-1/PI3K/Akt signalling pathway to reduce autophagy in gestational diabetes. | 0 |
| 38870061 | 2024 | AMBRA1 levels predict resistance to MAPK inhibitors in melanoma. | 0 |
| 37806389 | 2024 | Ambra1 in exosomes secreted by HK-2 cells damaged by supersaturated oxalate induce mitophagy and autophagy-ferroptosis in normal HK-2 cells to participate in the occurrence of kidney stones. | 4 |
| 38424148 | 2024 | AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner. | 0 |
| 38497391 | 2024 | sh- Ambra1 inhibits IRS-1/PI3K/Akt signalling pathway to reduce autophagy in gestational diabetes. | 0 |
| 38870061 | 2024 | AMBRA1 levels predict resistance to MAPK inhibitors in melanoma. | 0 |
| 37225761 | 2023 | Ambra1 modulates the sensitivity of mantle cell lymphoma to palbociclib by regulating cyclin D1. | 0 |
| 37225761 | 2023 | Ambra1 modulates the sensitivity of mantle cell lymphoma to palbociclib by regulating cyclin D1. | 0 |
| 34798798 | 2022 | AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability. | 16 |
| 36082712 | 2022 | [Homocysteine promotes human hepatocyte autophagy through activating the activating molecule in beclin-1-regulated autophage (AMBRA1)]. | 0 |
| 36243772 | 2022 | The Cancermuts software package for the prioritization of missense cancer variants: a case study of AMBRA1 in melanoma. | 6 |
| 34798798 | 2022 | AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability. | 16 |
| 36082712 | 2022 | [Homocysteine promotes human hepatocyte autophagy through activating the activating molecule in beclin-1-regulated autophage (AMBRA1)]. | 0 |
Citation
Dessen P
AMBRA1 (autophagy and beclin 1 regulator 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-02-01
Online version: http://atlasgeneticsoncology.org/gene/53689/ambra1-(autophagy-and-beclin-1-regulator-1)
