BLVRA (biliverdin reductase A)

2014-02-01  

Identity

HGNC
LOCATION
7p13
LOCUSID
ALIAS
BLVR,BVR,BVRA
FUSION GENES

Other Information

Locus ID:

NCBI: 644
MIM: 109750
HGNC: 1062
Ensembl: ENSG00000106605

Variants:

dbSNP: 644
ClinVar: 644
TCGA: ENSG00000106605
COSMIC: BLVRA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106605ENST00000265523P53004
ENSG00000106605ENST00000265523A0A140VJF4
ENSG00000106605ENST00000402924P53004
ENSG00000106605ENST00000402924A0A140VJF4
ENSG00000106605ENST00000424330C9J1E1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Porphyrin and chlorophyll metabolismKEGGko00860
Porphyrin and chlorophyll metabolismKEGGhsa00860
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of porphyrinsREACTOMER-HSA-189445
Heme degradationREACTOMER-HSA-189483

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124568812002Biliverdin reductase: a major physiologic cytoprotectant.240
204300372010Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin.46
184632902008Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling.41
149884082004Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1.37
157411662005Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells.32
196901642009Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase.32
257263842015Biliverdin reductase isozymes in metabolism.31
214830942011Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment.29
212417992011Biliverdin reductase--a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment.25
172277572007Human biliverdin reductase, a previously unknown activator of protein kinase C betaII.23

Citation

Dessen P

BLVRA (biliverdin reductase A)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53690/blvra-(biliverdin-reductase-a)