APOC2 (apolipoprotein C2)

2014-02-01  

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
APO-CII,APOC-II

Other Information

Locus ID:

NCBI: 344
MIM: 608083
HGNC: 609
Ensembl: ENSG00000234906

Variants:

dbSNP: 344
ClinVar: 344
TCGA: ENSG00000234906
COSMIC: APOC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000234906ENST00000252490P02655
ENSG00000234906ENST00000252490A0A024R0T9
ENSG00000234906ENST00000585786Q6P163
ENSG00000234906ENST00000590360P02655
ENSG00000234906ENST00000590360A0A024R0T9
ENSG00000234906ENST00000591597V9GYJ8
ENSG00000234906ENST00000592257V9GZ01

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
Chylomicron-mediated lipid transportREACTOMER-HSA-174800
HDL-mediated lipid transportREACTOMER-HSA-194223
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164742099MTTPGenePathwayassociated

References

Pubmed IDYearTitleCitations
207143482010Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.246
208646722010Genetic variants influencing circulating lipid levels and risk of coronary artery disease.180
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
117518632002Macromolecular crowding accelerates amyloid formation by human apolipoprotein C-II.67
120321512002Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.58
222395542012Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia.46
178558072007Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery.36
219431582011Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.34
236318282013Identification of potential bladder cancer markers in urine by abundant-protein depletion coupled with quantitative proteomics.30
203313782010Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.29

Citation

Dessen P

APOC2 (apolipoprotein C2)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53696/apoc2-(apolipoprotein-c2)