APOC2 (apolipoprotein C2)

2014-02-01  

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
APO-CII,APOC-II

Other Information

Locus ID:

NCBI: 344
MIM: 608083
HGNC: 609
Ensembl: ENSG00000234906

Variants:

dbSNP: 344
ClinVar: 344
TCGA: ENSG00000234906
COSMIC: APOC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000234906ENST00000252490P02655
ENSG00000234906ENST00000252490A0A024R0T9
ENSG00000234906ENST00000585786Q6P163
ENSG00000234906ENST00000590360P02655
ENSG00000234906ENST00000590360A0A024R0T9
ENSG00000234906ENST00000591597V9GYJ8
ENSG00000234906ENST00000592257V9GZ01

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
Chylomicron-mediated lipid transportREACTOMER-HSA-174800
HDL-mediated lipid transportREACTOMER-HSA-194223
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164742099MTTPGenePathwayassociated

References

Pubmed IDYearTitleCitations
370941172023Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase.6
371553552023Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation.0
380034842023Sequence Variant Analysis of the APOCII Locus among an Arab Cohort.0
370941172023Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase.6
371553552023Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation.0
380034842023Sequence Variant Analysis of the APOCII Locus among an Arab Cohort.0
349218212022Association of the lipoprotein lipase and Apolipoprotein C-II gene polymorphisms with risk of dyslipidemia in smokers and non-smokers male.2
358207052022ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF.19
349218212022Association of the lipoprotein lipase and Apolipoprotein C-II gene polymorphisms with risk of dyslipidemia in smokers and non-smokers male.2
358207052022ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF.19
339345962021Apolipoprotein C-II and C-III preferably transfer to both high-density lipoprotein (HDL)2 and the larger HDL3 from very low-density lipoprotein (VLDL).5
341854182021Deregulation of apolipoprotein C2 gene in cancer: A potential metabolic vulnerability.2
344591272021Apolipoprotein C-II induces EMT to promote gastric cancer peritoneal metastasis via PI3K/AKT/mTOR pathway.37
345568082021Plasma apolipopotein C-2 elevation is associated with Takayasu arteritis.0
339345962021Apolipoprotein C-II and C-III preferably transfer to both high-density lipoprotein (HDL)2 and the larger HDL3 from very low-density lipoprotein (VLDL).5

Citation

Dessen P

APOC2 (apolipoprotein C2)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53696/apoc2-(apolipoprotein-c2)