RNASEH2A (ribonuclease H2 subunit A)

2014-02-01  

Identity

HGNC
RNASEH2A
LOCATION
19p13.13
LOCUSID
10535
ALIAS
AGS4,JUNB,RNASEHI,RNHIA,RNHL,THSD8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10535
MIM: 606034
HGNC: 18518
Ensembl: ENSG00000104889

Variants:

dbSNP: 10535
ClinVar: 10535
TCGA: ENSG00000104889
COSMIC: RNASEH2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104889ENST00000221486O75792
ENSG00000104889ENST00000590121A0A2R8Y658
ENSG00000104889ENST00000646769A0A2R8Y606

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA replicationKEGGko03030
DNA replicationKEGGhsa03030

References

Pubmed IDYearTitleCitations
341650252022Hypoxia-induced RNASEH2A limits activation of cGAS-STING signaling in HCC and predicts poor prognosis.7
353275602022Decrease in RNase HII and Accumulation of lncRNAs/DNA Hybrids: A Causal Implication in Psoriasis?2
355008432022Depletion of RNASEH2 Activity Leads to Accumulation of DNA Double-strand Breaks and Reduced Cellular Survivability in T Cell Leukemia.3
356187152022RNase H2, mutated in Aicardi-Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation.24
365777842022RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells.8
369233132022Ribonuclease H2 Subunit A Preserves Genomic Integrity and Promotes Prostate Cancer Progression.2
341650252022Hypoxia-induced RNASEH2A limits activation of cGAS-STING signaling in HCC and predicts poor prognosis.7
353275602022Decrease in RNase HII and Accumulation of lncRNAs/DNA Hybrids: A Causal Implication in Psoriasis?2
355008432022Depletion of RNASEH2 Activity Leads to Accumulation of DNA Double-strand Breaks and Reduced Cellular Survivability in T Cell Leukemia.3
356187152022RNase H2, mutated in Aicardi-Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation.24
365777842022RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells.8
369233132022Ribonuclease H2 Subunit A Preserves Genomic Integrity and Promotes Prostate Cancer Progression.2
342547282021Long noncoding RNA LINC01287 promotes proliferation and inhibits apoptosis of lung adenocarcinoma cells via the miR-3529-5p/RNASEH2A axis under the competitive endogenous RNA pattern.8
342547282021Long noncoding RNA LINC01287 promotes proliferation and inhibits apoptosis of lung adenocarcinoma cells via the miR-3529-5p/RNASEH2A axis under the competitive endogenous RNA pattern.8
333535572020Germline variation of Ribonuclease H2 genes in ovarian cancer patients.0

Citation

Dessen P

RNASEH2A (ribonuclease H2 subunit A)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53702/rnaseh2a-(ribonuclease-h2-subunit-a)