Identity
HGNC
LOCATION
19p13.13
LOCUSID
ALIAS
AGS4,JUNB,RNASEHI,RNHIA,RNHL,THSD8
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10535
MIM: 606034
HGNC: 18518
Ensembl: ENSG00000104889
Variants:
dbSNP: 10535
ClinVar: 10535
TCGA: ENSG00000104889
COSMIC: RNASEH2A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000104889 | ENST00000221486 | O75792 |
| ENSG00000104889 | ENST00000590121 | A0A2R8Y658 |
| ENSG00000104889 | ENST00000646769 | A0A2R8Y606 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| DNA replication | KEGG | ko03030 |
| DNA replication | KEGG | hsa03030 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34165025 | 2022 | Hypoxia-induced RNASEH2A limits activation of cGAS-STING signaling in HCC and predicts poor prognosis. | 7 |
| 35327560 | 2022 | Decrease in RNase HII and Accumulation of lncRNAs/DNA Hybrids: A Causal Implication in Psoriasis? | 2 |
| 35500843 | 2022 | Depletion of RNASEH2 Activity Leads to Accumulation of DNA Double-strand Breaks and Reduced Cellular Survivability in T Cell Leukemia. | 3 |
| 35618715 | 2022 | RNase H2, mutated in Aicardi-Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation. | 24 |
| 36577784 | 2022 | RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells. | 8 |
| 36923313 | 2022 | Ribonuclease H2 Subunit A Preserves Genomic Integrity and Promotes Prostate Cancer Progression. | 2 |
| 34165025 | 2022 | Hypoxia-induced RNASEH2A limits activation of cGAS-STING signaling in HCC and predicts poor prognosis. | 7 |
| 35327560 | 2022 | Decrease in RNase HII and Accumulation of lncRNAs/DNA Hybrids: A Causal Implication in Psoriasis? | 2 |
| 35500843 | 2022 | Depletion of RNASEH2 Activity Leads to Accumulation of DNA Double-strand Breaks and Reduced Cellular Survivability in T Cell Leukemia. | 3 |
| 35618715 | 2022 | RNase H2, mutated in Aicardi-Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation. | 24 |
| 36577784 | 2022 | RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells. | 8 |
| 36923313 | 2022 | Ribonuclease H2 Subunit A Preserves Genomic Integrity and Promotes Prostate Cancer Progression. | 2 |
| 34254728 | 2021 | Long noncoding RNA LINC01287 promotes proliferation and inhibits apoptosis of lung adenocarcinoma cells via the miR-3529-5p/RNASEH2A axis under the competitive endogenous RNA pattern. | 8 |
| 34254728 | 2021 | Long noncoding RNA LINC01287 promotes proliferation and inhibits apoptosis of lung adenocarcinoma cells via the miR-3529-5p/RNASEH2A axis under the competitive endogenous RNA pattern. | 8 |
| 33353557 | 2020 | Germline variation of Ribonuclease H2 genes in ovarian cancer patients. | 0 |
Citation
Dessen P
RNASEH2A (ribonuclease H2 subunit A)
Atlas Genet Cytogenet Oncol Haematol. 2014-02-01
Online version: http://atlasgeneticsoncology.org/gene/53702/rnaseh2a-(ribonuclease-h2-subunit-a)
