USP13 (ubiquitin specific peptidase 13)

2014-02-01  

Identity

HGNC
LOCATION
3q26.33
LOCUSID
ALIAS
ISOT3,IsoT-3
FUSION GENES

Other Information

Locus ID:

NCBI: 8975
MIM: 603591
HGNC: 12611
Ensembl: ENSG00000058056

Variants:

dbSNP: 8975
ClinVar: 8975
TCGA: ENSG00000058056
COSMIC: USP13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000058056ENST00000263966Q92995
ENSG00000058056ENST00000263966A0A0A6YZ17
ENSG00000058056ENST00000496897Q92995
ENSG00000058056ENST00000497155H7C5J3
ENSG00000058056ENST00000497380H7C502

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
367324322023USP13 promotes breast cancer metastasis through FBXL14-induced Twist1 ubiquitination.2
371518892023Deubiquitinase USP13 regulates glycolytic reprogramming and progression in osteosarcoma by stabilizing METTL3/m(6)A/ATG5 axis.6
373118112023USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation.7
377769172023USP13 deubiquitinates p62/SQSTM1 to induce autophagy and Nrf2 release for activating antioxidant response genes.2
380430622023Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin.0
380933672023USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity.1
367324322023USP13 promotes breast cancer metastasis through FBXL14-induced Twist1 ubiquitination.2
371518892023Deubiquitinase USP13 regulates glycolytic reprogramming and progression in osteosarcoma by stabilizing METTL3/m(6)A/ATG5 axis.6
373118112023USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation.7
377769172023USP13 deubiquitinates p62/SQSTM1 to induce autophagy and Nrf2 release for activating antioxidant response genes.2
380430622023Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin.0
380933672023USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity.1
355838462022USP13 genetics and expression in a family with thyroid cancer.5
360373642022USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer.14
365647672022ncRNA-mediated overexpression of ubiquitin-specific proteinase 13 contributes to the progression of prostate cancer via modulating AR signaling, DNA damage repair and immune infiltration.1

Citation

Dessen P

USP13 (ubiquitin specific peptidase 13)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53713/usp13-(ubiquitin-specific-peptidase-13)