HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3)

2013-11-01  

Identity

HGNC
LOCATION
9q22.32
LOCUSID
ALIAS
EDH17B3,SDR12C2
FUSION GENES

Other Information

Locus ID:

NCBI: 3293
MIM: 605573
HGNC: 5212
Ensembl: ENSG00000130948

Variants:

dbSNP: 3293
ClinVar: 3293
TCGA: ENSG00000130948
COSMIC: HSD17B3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130948ENST00000375262P37058
ENSG00000130948ENST00000375263P37058
ENSG00000130948ENST00000375263Q6FH62
ENSG00000130948ENST00000467499A0A3B3ITW2
ENSG00000130948ENST00000648146A0A0S2Z3U6
ENSG00000130948ENST00000648332A0A0S2Z406
ENSG00000130948ENST00000648799A0A3B3ITT4
ENSG00000130948ENST00000650005A0A0S2Z413
ENSG00000130948ENST00000650386A0A0S2Z3V7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Steroid hormone biosynthesisKEGGhsa00140
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Synthesis of very long-chain fatty acyl-CoAsREACTOMER-HSA-75876
Metabolism of steroid hormonesREACTOMER-HSA-196071
Androgen biosynthesisREACTOMER-HSA-193048

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
361548872023Lessons from 17β-HSD3 deficiency: Clinical spectrum and complex molecular basis in Chinese patients.0
365637632023Molecular mechanisms underlying the defects of two novel mutations in the HSD17B3 gene found in the Tunisian population.0
361548872023Lessons from 17β-HSD3 deficiency: Clinical spectrum and complex molecular basis in Chinese patients.0
365637632023Molecular mechanisms underlying the defects of two novel mutations in the HSD17B3 gene found in the Tunisian population.0
348857492021Substituted Aryl Benzylamines as Potent and Selective Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 3.0
348857492021Substituted Aryl Benzylamines as Potent and Selective Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 3.0
316142072020Evaluation of 17β-hydroxysteroid dehydrogenase activity using androgen receptor-mediated transactivation.9
323723062020The novel founder homozygous V225M mutation in the HSD17B3 gene causes aberrant splicing and XY-DSD.2
316142072020Evaluation of 17β-hydroxysteroid dehydrogenase activity using androgen receptor-mediated transactivation.9
323723062020The novel founder homozygous V225M mutation in the HSD17B3 gene causes aberrant splicing and XY-DSD.2
269561912017Novel cases of Tunisian patients with mutations in the gene encoding 17β-hydroxysteroid dehydrogenase type 3 and a founder effect.5
287747652017Novel mutations of HSD17B3 in three Chinese patients with 46,XY Disorders of Sex Development.3
288598742017Biochemical Analysis of Four Missense Mutations in the HSD17B3 Gene Associated With 46,XY Disorders of Sex Development in Egyptian Patients.3
269561912017Novel cases of Tunisian patients with mutations in the gene encoding 17β-hydroxysteroid dehydrogenase type 3 and a founder effect.5
287747652017Novel mutations of HSD17B3 in three Chinese patients with 46,XY Disorders of Sex Development.3

Citation

Dessen P

HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53741/hsd17b3-(hydroxysteroid-17-beta-dehydrogenase-3)