H1-4 (H1.4 linker histone, cluster member)

2014-01-01  

Identity

HGNC
LOCATION
6p22.2
LOCUSID
ALIAS
H1.4,H1E,H1F4,H1s-4,HIST1H1E,RMNS,dJ221C16.5

Other Information

Locus ID:

NCBI: 3008
MIM: 142220
HGNC: 4718
Ensembl: ENSG00000168298

Variants:

dbSNP: 3008
ClinVar: 3008
TCGA: ENSG00000168298
COSMIC: H1-4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168298ENST00000304218P10412
ENSG00000168298ENST00000304218A3R0T8

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptosis induced DNA fragmentationREACTOMER-HSA-140342
Activation of DNA fragmentation factorREACTOMER-HSA-211227
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584

References

Pubmed IDYearTitleCitations
319108942020Frameshift mutations at the C-terminus of HIST1H1E result in a specific DNA hypomethylation signature.30
319108942020Frameshift mutations at the C-terminus of HIST1H1E result in a specific DNA hypomethylation signature.30
314000682019HIST1H1E heterozygous protein-truncating variants cause a recognizable syndrome with intellectual disability and distinctive facial gestalt: A study to clarify the HIST1H1E syndrome phenotype in 30 individuals.9
314000682019HIST1H1E heterozygous protein-truncating variants cause a recognizable syndrome with intellectual disability and distinctive facial gestalt: A study to clarify the HIST1H1E syndrome phenotype in 30 individuals.9
301562642018Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26.8
301562642018Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26.8
262096082016Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.20
262096082016Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.20
250480042015Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia.84
250480042015Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia.84
244350472014Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.97
248738822014Dynamics and dispensability of variant-specific histone H1 Lys-26/Ser-27 and Thr-165 post-translational modifications.8
244350472014Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.97
248738822014Dynamics and dispensability of variant-specific histone H1 Lys-26/Ser-27 and Thr-165 post-translational modifications.8
224259852012The N-terminal domain determines the affinity and specificity of H1 binding to chromatin.10

Citation

Dessen P

H1-4 (H1.4 linker histone, cluster member)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53757/h1-4-(h1-4-linker-histone-cluster-member)