AMY1A (amylase alpha 1A)

2014-01-01  

Identity

HGNC
AMY1A
LOCATION
1p21.1
LOCUSID
276
ALIAS
AMY1

Other Information

Locus ID:

NCBI: 276
MIM: 104700
HGNC: 474
Ensembl: ENSG00000237763

Variants:

dbSNP: 276
ClinVar: 276
TCGA: ENSG00000237763
COSMIC: AMY1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000237763ENST00000370083P04745
ENSG00000237763ENST00000422549Q5T084
ENSG00000237763ENST00000430659Q5T085

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Starch and sucrose metabolismKEGGko00500
Starch and sucrose metabolismKEGGhsa00500
Metabolic pathwaysKEGGhsa01100
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Digestion of dietary carbohydrateREACTOMER-HSA-189085

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
178282632007Diet and the evolution of human amylase gene copy number variation.371
157086462005Human salivary alpha-amylase reactivity in a psychosocial stress paradigm.92
209672202010Individual differences in AMY1 gene copy number, salivary α-amylase levels, and the perception of oral starch.48
246868482014Low copy number of the salivary amylase gene predisposes to obesity.47
229145932012Exercise-induced noradrenergic activation enhances memory consolidation in both normal aging and patients with amnestic mild cognitive impairment.38
224921222012High endogenous salivary amylase activity is associated with improved glycemic homeostasis following starch ingestion in adults.29
253948252015Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children.29
229651872012Copy number polymorphism of the salivary amylase gene: implications in human nutrition research.18
175933032007Interaction of salivary alpha-amylase and amylase-binding-protein A (AbpA) of Streptococcus gordonii with glucosyltransferase of S. gordonii and Streptococcus mutans.17
151945032004Inhibitory effects of tannin on human salivary alpha-amylase.13

Citation

Dessen P

AMY1A (amylase alpha 1A)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53776/amy1a-(amylase-alpha-1a)