Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9128
MIM: 607795
HGNC: 17349
Ensembl: ENSG00000136875
Variants:
dbSNP: 9128
ClinVar: 9128
TCGA: ENSG00000136875
COSMIC: PRPF4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000136875 | ENST00000374198 | O43172 |
| ENSG00000136875 | ENST00000374198 | Q5T1M7 |
| ENSG00000136875 | ENST00000374199 | O43172 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31445970 | 2019 | PRPF4 is a novel therapeutic target for the treatment of breast cancer by influencing growth, migration, invasion, and apoptosis of breast cancer cells via p38 MAPK signaling pathway. | 7 |
| 31445970 | 2019 | PRPF4 is a novel therapeutic target for the treatment of breast cancer by influencing growth, migration, invasion, and apoptosis of breast cancer cells via p38 MAPK signaling pathway. | 7 |
| 29787735 | 2018 | PRP4 kinase induces actin rearrangement and epithelial-mesenchymal transition through modulation of the actin-binding protein cofilin. | 12 |
| 29787735 | 2018 | PRP4 kinase induces actin rearrangement and epithelial-mesenchymal transition through modulation of the actin-binding protein cofilin. | 12 |
| 24419317 | 2014 | PRPF4 mutations cause autosomal dominant retinitis pigmentosa. | 57 |
| 25383878 | 2014 | Identification of a PRPF4 loss-of-function variant that abrogates U4/U6.U5 tri-snRNP integration and is associated with retinitis pigmentosa. | 19 |
| 24419317 | 2014 | PRPF4 mutations cause autosomal dominant retinitis pigmentosa. | 57 |
| 25383878 | 2014 | Identification of a PRPF4 loss-of-function variant that abrogates U4/U6.U5 tri-snRNP integration and is associated with retinitis pigmentosa. | 19 |
| 24003220 | 2013 | Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches. | 17 |
| 24003220 | 2013 | Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches. | 17 |
| 18687998 | 2008 | Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer. | 13 |
| 18687998 | 2008 | Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer. | 13 |
| 17998396 | 2007 | PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores. | 40 |
| 17998396 | 2007 | PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores. | 40 |
| 11971898 | 2002 | Central region of the human splicing factor Hprp3p interacts with Hprp4p. | 17 |
Citation
Dessen P
PRPF4 (pre-mRNA processing factor 4)
Atlas Genet Cytogenet Oncol Haematol. 2014-01-01
Online version: http://atlasgeneticsoncology.org/gene/53784/prpf4-(pre-mrna-processing-factor-4)
